CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog)
1_MMLPK 6_ PGTYY 11_ LPWEV 16_ SAGQV 21_ PDGST 26_ LRTFG 31_ RLCLY 36_ DMIQS 41_ RVTLM 46_ AQHGS 51_ DQHQV 56_ LVCTK 61_ LVEPF 66_ HAQVG 71_ SLYIV 76_ LGELQ 81_ HQQDR 86_ GSVVK 91_ ARVLT 96_ CVEGM 101_ NLPLL 106_ EQAIR 111_ EQRLY 116_KQERG
1: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097)