Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP)
1_MSAAL 6_ LRRGL 11_ ELLAA 16_ SEAPR 21_ DPPGQ 26_ AKPRG 31_ APVKR 36_ PRKTK 41_ AIQAQ 46_ KLRNS 51_ AKGKV 56_ PKSAL 61_ DEYRK 66_ RECRD 71_ HLRVN 76_ LKFLT 81_ RTRST 86_ VAESV 91_ SQQIL 96_ RQNRG 101_ RKACD 106_ RPVAK 111_ TKKKK 116_ AEGTV 121_ FTEED 126_ FQKFQ 131_QEYFG
1: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266)