HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein)
1_MATAQ 6_ LQRTP 11_ MSALV 16_ FPNKI 21_ STEHQ 26_ SLVLV 31_ KRLLA 36_ VSVSC 41_ ITYLR 46_ GIFPE 51_ CAYGT 56_ RYLDD 61_ LCVKI 66_ LREDK 71_ NCPGS 76_ TQLVK 81_ WMLGC 86_ YDALQ 91_ KKYLR 96_ MVVLA 101_ VYTNP 106_ EDPQT 111_ ISECY 116_ QFKFK 121_ YTNNG 126_ PLMDF 131_ ISKNQ 136_ SNESS 141_ MLSTD 146_ TKKAS 151_ ILLIR 156_ KIYIL 161_ MQNLG 166_ PLPND 171_ VCLTM 176_ KLFYY 181_ DEVTP 186_ PDYQP 191_ PGFKD 196_ GDCEG 201_ VIFEG 206_ EPMYL 211_ NVGEV 216_ STPFH 221_ IFKVK 226_ VTTER 231_ ERMEN 236_ IDSTI 241_ LSPKQ 246_ IKTPF 251_ QKILR 256_ DKDVE 261_ DEQEH 266_ YTSDD 271_ LDIET 276_ KMEEQ 281_ EKNPA 286_ SSELE 291_ EPSLV 296_ CEEDE 301_ IMRSK 306_ ESPDL 311_ SISHS 316_ QVEQL 321_ VNKTS 326_ ELDMS 331_ ESKTR 336_ SGKVF 341_ QNKMA 346_ NGNQP 351_ VKSSK 356_ ENRKR 361_ SQHES 366_ GRIVL 371_ HHFDS 376_ SSQES 381_ VPKRR 386_KFSEP
1: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes