EZH inhibitory protein
1_MATQS 6_ DMEKE 11_ QKHQQ 16_ DEGQG 21_ GLNNE 26_ TALAS 31_ GDACG 36_ TGNQD 41_ PAASV 46_ TTVSS 51_ QASPS 56_ GGAAL 61_ SSSTA 66_ GSSAA 71_ AATSA 76_ AIFIT 81_ DEASG 86_ LPIIA 91_ AVLTE 96_ RHSDR 101_ QDCRS 106_ PHEVF 111_ GCVVP 116_ EGGSQ 121_ AAVGP 126_ QKATG 131_ HADEH 136_ LAQTK 141_ SPGNS 146_ RRRKQ 151_ PCRNQ 156_ AAPAQ 161_ KPPGR 166_ RLFPE 171_ PLPPS 176_ SPGFR 181_ PSSYP 186_ CSGAS 191_ TSSQA 196_ TQPGP 201_ ALLSH 206_ ASEAR 211_ PATRS 216_ RITLV 221_ ASALR 226_ RRASG 231_ PGPVI 236_ RGCTA 241_ QPGPA 246_ FPHRA 251_ THLDP 256_ ARLSP 261_ ESAPG 266_ PARRG 271_ RASVP 276_ GPARR 281_ GCDSA 286_ PGPAR 291_ RGRDS 296_ APVSA 301_ PRGRD 306_ SAPGS 311_ ARRGR 316_ DSAPG 321_ PALRV 326_ RTARS 331_ DAGHR 336_ STSTT 341_ PGTGL 346_ RSRST 351_ QQRSA 356_ LLSRR 361_ SLSGS 366_ ADENP 371_ SCGTG 376_ SERLA 381_ FQSRS 386_ GSPDP 391_ EVPSR 396_ ASPPV 401_ WHAVR 406_ MRASS 411_ PSPPG 416_ RFFLP 421_ IPQQW 426_ DESSS 431_ SSYAS 436_ NSSSP 441_ SRSPG 446_ LSPSS 451_ PSPEF 456_ LGLRS 461_ ISTPS 466_ PESLR 471_ YALMP 476_ EFYAL 481_ SPVPP 486_ EEQAE 491_ IESTA 496_HPATP
1: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity)