Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1)
1_MAARG 6_ RRAWL 11_ SVLLG 16_ LVLGF 21_ VLASR 26_ LVLPR 31_ ASELK 36_ RAGPR 41_ RRASP 46_ EGCRS 51_ GQAAA 56_ SQAGG 61_ ARGDA 66_ RGAQL 71_ WPPGS 76_ DPDGG 81_ PRDRN 86_ FLFVG 91_ VMTAQ 96_ KYLQT 101_ RAVAA 106_ YRTWS 111_ KTIPG 116_ KVQFF 121_ SSEGS 126_ DTSVP 131_ IPVVP 136_ LRGVD 141_ DSYPP 146_ QKKSF 151_ MMLKY 156_ MHDHY 161_ LDKYE 166_ WFMRA 171_ DDDVY 176_ IKGDR 181_ LENFL 186_ RSLNS 191_ SEPLF 196_ LGQTG 201_ LGTTE 206_ EMGKL 211_ ALEPG 216_ ENFCM 221_ GGPGV 226_ IMSRE 231_ VLRRM 236_ VPHIG 241_ KCLRE 246_ MYTTH 251_ EDVEV 256_ GRCVR 261_ RFAGV 266_ QCVWS 271_ YEMQQ 276_ LFYEN 281_ YEQNK 286_ KGYIR 291_ DLHNS 296_ KIHQA 301_ ITLHP 306_ NKNPP 311_ YQYRL 316_ HSYML 321_ SRKIS 326_ ELRHR 331_ TIQLH 336_ REIVL 341_ MSKYS 346_ NTEIH 351_ KEDLQ 356_ LGIPP 361_ SFMRF 366_ QPRQR 371_ EEILE 376_ WEFLT 381_ GKYLY 386_ SAVDG 391_ QPPRR 396_ GMDSA 401_ QREAL 406_ DDIVM 411_ QVMEM 416_ INANA 421_ KTRGR 426_ IIDFK 431_ EIQYG 436_ YRRVN 441_ PMYGA 446_ EYILD 451_ LLLLY 456_ KKHKG 461_ KKMTV 466_ PVRRH 471_ AYLQQ 476_ TFSKI 481_ QFVEH 486_ EELDA 491_ QELAK 496_ RINQE 501_ SGSLS 506_ FLSNS 511_ LKKLV 516_ PFQLP 521_ GSKSE 526_ HKEPK 531_ DKKIN 536_ ILIPL 541_ SGRFD 546_ MFVRF 551_ MGNFE 556_ KTCLI 561_ PNQNV 566_ KLVVL 571_ LFNSD 576_ SNPDK 581_ AKQVE 586_ LMRDY 591_ RIKYP 596_ KADMQ 601_ ILPVS 606_ GEFSR 611_ ALALE 616_ VGSSQ 621_ FNNES 626_ LLFFC 631_ DVDLV 636_ FTTEF 641_ LQRCR 646_ ANTVL 651_ GQQIY 656_ FPIIF 661_ SQYDP 666_ KIVYS 671_ GKVPS 676_ DNHFA 681_ FTQKT 686_ GFWRN 691_ YGFGI 696_ TCIYK 701_ GDLVR 706_ VGGFD 711_ VSIQG 716_ WGLED 721_ VDLFN 726_ KVVQA 731_ GLKTF 736_ RSQEV 741_ GVVHV 746_ HHPVF 751_ CDPNL 756_ DPKQY 761_ KMCLG 766_ SKAST 771_ YGSTQ 776_ QLAEM 781_ WLEKN 786_ DPSYS 791_ KSSNN 796_NGSVR
1: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling