COMM domain-containing protein 2
1_MLLEL 6_ SEEHK 11_ EHLAF 16_ LPQVD 21_ SAVVA 26_ EFGRI 31_ AVEFL 36_ RRGAN 41_ PKIYE 46_ GAARK 51_ LNVSS 56_ DTVQH 61_ GVEGL 66_ TYLLT 71_ ESSKL 76_ MISEL 81_ DFQDS 86_ VFVLG 91_ FSEEL 96_ NKLLL 101_ QLYLD 106_ NRKEI 111_ RTILS 116_ ELAPS 121_ LPSYH 126_ NLEWR 131_ LDVQL 136_ ASRSL 141_ RQQIK 146_ PAVTI 151_ KLHLN 156_ QNGDH 161_ NTKVL 166_ QTDPA 171_ TLLHL 176_ VQQLE 181_ QALEE 186_ MKTNH 191_CRRVV
1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966)