Gene name: METTL23

Uniprot entry:

Q86XA0

Protein names:

Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23)

Protein sequence:

1_MYVWP 6_ CAVVL 11_ AQYLW 16_ FHRRS 21_ LPGKA 26_ ILEIG 31_ AGVSL 36_ PGILA 41_ AKCGA 46_ EVILS 51_ DSSEL 56_ PHCLE 61_ VCRQS 66_ CQMNN 71_ LPHLQ 76_ VVGLT 81_ WGHIS 86_ WDLLA 91_ LPPQD 96_ IILAS 101_ DVFFE 106_ PEDFE 111_ DILAT 116_ IYFLM 121_ HKNPK 126_ VQLWS 131_ TYQVR 136_ SADWS 141_ LEALL 146_ YKWDM 151_ KCVHI 156_ PLESF 161_ DADKE 166_ DIAES 171_ TLPGR 176_ HTVEM 181_LVISF

Protein annotations

Protein functions:

1: Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity)