Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)
1_MAALR 6_ RLLWP 11_ PPRVS 16_ PPLCA 21_ HQPLL 26_ GPWGR 31_ PAVTT 36_ LGLPG 41_ RPFSS 46_ REDEE 51_ RAVAE 56_ AAWRR 61_ RRRWG 66_ ELSVA 71_ AAAGG 76_ GLVGL 81_ VCYQL 86_ YGDPR 91_ AGSPA 96_ TGRPS 101_ KSAAT 106_ EPEDP 111_ PRGRG 116_ MLPIP 121_ VAAAK 126_ ETVAI 131_ GRTDI 136_ EDLDL 141_ YATSR 146_ ERRFR 151_ LFASI 156_ ECEGQ 161_ LFMTP 166_ YDFIL 171_ AVTTD 176_ EPKVA 181_ KTWKS 186_ LSKQE 191_ LNQML 196_ AETPP 201_ VWKGS 206_ SKLFR 211_ NLKEK 216_ GVISY 221_ TEYLF 226_ LLCIL 231_ TKPHA 236_ GFRIA 241_ FNMFD 246_ TDGNE 251_ MVDKK 256_ EFLVL 261_ QEIFR 266_ KKNEK 271_ REIKG 276_ DEEKR 281_ AMLRL 286_ QLYGY 291_ HSPTN 296_ SVLKT 301_ DAEEL 306_ VSRSY 311_ WDTLR 316_ RNTSQ 321_ ALFSD 326_ LAERA 331_ DDITS 336_ LVTDT 341_ TLLVH 346_ FFGKK 351_ GKAEL 356_ NFEDF 361_ YRFMD 366_ NLQTE 371_ VLEIE 376_ FLSYS 381_ NGMNT 386_ ISEED 391_ FAHIL 396_ LRYTN 401_ VENTS 406_ VFLEN 411_ VRYSI 416_ PEEKG 421_ ITFDE 426_ FRSFF 431_ QFLNN 436_ LEDFA 441_ IALNM 446_ YNFAS 451_ RSIGQ 456_ DEFKR 461_ AVYVA 466_ TGLKF 471_ SPHLV 476_ NTVFK 481_ IFDVD 486_ KDDQL 491_ SYKEF 496_ IGIMK 501_ DRLHR 506_ GFRGY 511_ KTVQK 516_ YPTFK 521_SCLKK
1: Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle (PubMed:29725115). Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium (PubMed:29725115). MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:29725115). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:29725115). At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:29725115). The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel (PubMed:29725115). The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses (PubMed:29725115). It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (By similarity)