Gene name: DHFR2

Uniprot entry:

Q86XF0

Protein names:

Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)

Protein sequence:

1_MFLLL 6_ NCIVA 11_ VSQNM 16_ GIGKN 21_ GDLPR 26_ PPLRN 31_ EFRYF 36_ QRMTT 41_ TSSVE 46_ GKQNL 51_ VIMGR 56_ KTWFS 61_ IPEKN 66_ RPLKD 71_ RINLV 76_ LSREL 81_ KEPPQ 86_ GAHFL 91_ ARSLD 96_ DALKL 101_ TERPE 106_ LANKV 111_ DMIWI 116_ VGGSS 121_ VYKEA 126_ MNHLG 131_ HLKLF 136_ VTRIM 141_ QDFES 146_ DTFFS 151_ EIDLE 156_ KYKLL 161_ PEYPG 166_ VLSDV 171_ QEGKH 176_ IKYKF 181_EVCEK

Protein annotations

Protein functions:

1: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR