Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)
1_MMAVD 6_ IEYRY 11_ NCMAP 16_ SLRQE 21_ RFAFK 26_ ISPKP 31_ SKPLR 36_ PCIQL 41_ SSKNE 46_ ASGMV 51_ APAVQ 56_ EKKVK 61_ KRVSF 66_ ADNQG 71_ LALTM 76_ VKVFS 81_ EFDDP 86_ LDMPF 91_ NITEL 96_ LDNIV 101_ SLTTA 106_ ESESF 111_ VLDFS 116_ QPSAD 121_ YLDFR 126_ NRLQA 131_ DHVCL 136_ ENCVL 141_ KDKAI 146_ AGTVK 151_ VQNLA 156_ FEKTV 161_ KIRMT 166_ FDTWK 171_ SYTDF 176_ PCQYV 181_ KDTYA 186_ GSDRD 191_ TFSFD 196_ ISLPE 201_ KIQSY 206_ ERMEF 211_ AVYYE 216_ CNGQT 221_ YWDSN 226_ RGKNY 231_ RIIRA 236_ ELKST 241_ QGMTK 246_ PHSGP 251_ DLGIS 256_ FDQFG 261_ SPRCS 266_ YGLFP 271_ EWPSY 276_LGYEK
1: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity)