Calcium homeostasis modulator protein 3 (Protein A)
1_MDKFR 6_ MLFQH 11_ FQSSS 16_ ESVMN 21_ GICLL 26_ LAAVT 31_ VKLYS 36_ SFDFN 41_ CPCLV 46_ HYNAL 51_ YGLGL 56_ LLTPP 61_ LALFL 66_ CGLLA 71_ NRQSV 76_ VMVEE 81_ WRRPA 86_ GHRRK 91_ DPGII 96_ RYMCS 101_ SVLQR 106_ ALAAP 111_ LVWIL 116_ LALLD 121_ GKCFV 126_ CAFSS 131_ SVDPE 136_ KFLDF 141_ ANMTP 146_ SQVQL 151_ FLAKV 156_ PCKED 161_ ELVRD 166_ SPARK 171_ AVSRY 176_ LRCLS 181_ QAIGW 186_ SVTLL 191_ LIIAA 196_ FLARC 201_ LRPCF 206_ DQTVF 211_ LQRRY 216_ WSNYV 221_ DLEQK 226_ LFDET 231_ CCEHA 236_ RDFAH 241_ RCVLH 246_ FFASM 251_ RSELQ 256_ ARGLR 261_ RGNAG 266_ RRLEL 271_ PAVPE 276_ PPEGL 281_ DSGSG 286_ KAHLR 291_ AISSR 296_ EQVDR 301_ LLSTW 306_ YSSKP 311_ PLDLA 316_ ASPGL 321_ CGGGL 326_ SHRAP 331_ TLALG 336_TRLSQ
1: Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-)