F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)
1_MNSVR 6_ AANRR 11_ PRRVS 16_ RPRPV 21_ QQQQQ 26_ QPPQQ 31_ PPPQP 36_ PQQQP 41_ PQQQP 46_ PPPPQ 51_ QQQQQ 56_ QPPPP 61_ PPPPP 66_ PLPQE 71_ RNNVG 76_ ERDDD 81_ VPADM 86_ VAEES 91_ GPGAQ 96_ NSPYQ 101_ LRRKT 106_ LLPKR 111_ TACPT 116_ KNSME 121_ GASTS 126_ TTENF 131_ GHRAK 136_ RARVS 141_ GKSQD 146_ LSAAP 151_ AEQYL 156_ QEKLP 161_ DEVVL 166_ KIFSY 171_ LLEQD 176_ LCRAA 181_ CVCKR 186_ FSELA 191_ NDPIL 196_ WKRLY 201_ MEVFE 206_ YTRPM 211_ MHPEP 216_ GKFYQ 221_ INPEE 226_ YEHPN 231_ PWKES 236_ FQQLY 241_ KGAHV 246_ KPGFA 251_ EHFYS 256_ NPARY 261_ KGREN 266_ MLYYD 271_ TIEDA 276_ LGGVQ 281_ EAHFD 286_ GLIFV 291_ HSGIY 296_ TDEWI 301_ YIESP 306_ ITMIG 311_ AAPGK 316_ VADKV 321_ IIENT 326_ RDSTF 331_ VFMEG 336_ SEDAY 341_ VGYMT 346_ IRFNP 351_ DDKSA 356_ QHHNA 361_ HHCLE 366_ ITVNC 371_ SPIID 376_ HCIIR 381_ STCTV 386_ GSAVC 391_ VSGQG 396_ ACPTI 401_ KHCNI 406_ SDCEN 411_ VGLYI 416_ TDHAQ 421_ GIYED 426_ NEISN 431_ NALAG 436_ IWVKN 441_ HGNPI 446_ IRRNH 451_ IHHGR 456_ DVGVF 461_ TFDHG 466_ MGYFE 471_ SCNIH 476_ RNRIA 481_ GFEVK 486_ AYANP 491_ TVVRC 496_ EIHHG 501_ QTGGI 506_ YVHEK 511_ GRGQF 516_ IENKI 521_ YANNF 526_ AGVWI 531_ TSNSD 536_ PTIRG 541_ NSIFN 546_ GNQGG 551_ VYIFG 556_ DGRGL 561_ IEGND 566_ IYGNA 571_ LAGIQ 576_ IRTNS 581_ CPIVR 586_ HNKIH 591_ DGQHG 596_ GIYVH 601_ EKGQG 606_ VIEEN 611_ EVYSN 616_ TLAGV 621_ WVTTG 626_ STPVL 631_ RRNRI 636_ HSGKQ 641_ VGVYF 646_ YDNGH 651_ GVLED 656_ NDIYN 661_ HMYSG 666_ VQIRT 671_ GSNPK 676_ IRRNK 681_ IWGGQ 686_ NGGIL 691_ VYNSG 696_ LGCIE 701_ DNEIF 706_ DNAMA 711_ GVWIK 716_ TDSNP 721_ TLRRN 726_ KIHDG 731_ RDGGI 736_ CIFNG 741_ GRGLL 746_ EENDI 751_ FRNAQ 756_ AGVLI 761_ STNSH 766_ PILRK 771_ NRIFD 776_ GFAAG 781_ IEITN 786_ HATAT 791_ LEGNQ 796_ IFNNR 801_ FGGLF 806_ LASGV 811_ NVTMK 816_ DNKIM 821_ NNQDA 826_ IEKAV 831_ SRGQC 836_ LYKIS 841_ SYTSY 846_ PMHDF 851_ YRCHT 856_ CNTTD 861_ RNAIC 866_ VNCIK 871_ KCHQG 876_ HDVEF 881_ IRHDR 886_ FFCDC 891_ GAGTL 896_ SNPCT 901_ LAGEP 906_ THDTD 911_ TLYDS 916_ APPIE 921_SNTLQ
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010)