ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)
1_MNWNK 6_ GGPGT 11_ KRGFG 16_ FGGFA 21_ ISAGK 26_ KEEPK 31_ LPQQS 36_ HSAFG 41_ ATSSS 46_ SGFGK 51_ SAPPQ 56_ LPSFY 61_ KIGSK 66_ RANFD 71_ EENAY 76_ FEDEE 81_ EDSSN 86_ VDLPY 91_ IPAEN 96_ SPTRQ 101_ QFHSK 106_ PVDSD 111_ SDDDP 116_ LEAFM 121_ AEVED 126_ QAARD 131_ MKRLE 136_ EKDKE 141_ RKNVK 146_ GIRDD 151_ IEEED 156_ DQEAY 161_ FRYMA 166_ ENPTA 171_ GVVQE 176_ EEEDN 181_ LEYDS 186_ DGNPI 191_ APTKK 196_ IIDPL 201_ PPIDH 206_ SEIDY 211_ PPFEK 216_ NFYNE 221_ HEEIT 226_ NLTPQ 231_ QLIDL 236_ RHKLN 241_ LRVSG 246_ AAPPR 251_ PGSSF 256_ AHFGF 261_ DEQLM 266_ HQIRK 271_ SEYTQ 276_ PTPIQ 281_ CQGVP 286_ VALSG 291_ RDMIG 296_ IAKTG 301_ SGKTA 306_ AFIWP 311_ MLIHI 316_ MDQKE 321_ LEPGD 326_ GPIAV 331_ IVCPT 336_ RELCQ 341_ QIHAE 346_ CKRFG 351_ KAYNL 356_ RSVAV 361_ YGGGS 366_ MWEQA 371_ KALQE 376_ GAEIV 381_ VCTPG 386_ RLIDH 391_ VKKKA 396_ TNLQR 401_ VSYLV 406_ FDEAD 411_ RMFDM 416_ GFEYQ 421_ VRSIA 426_ SHVRP 431_ DRQTL 436_ LFSAT 441_ FRKKI 446_ EKLAR 451_ DILID 456_ PIRVV 461_ QGDIG 466_ EANED 471_ VTQIV 476_ EILHS 481_ GPSKW 486_ NWLTR 491_ RLVEF 496_ TSSGS 501_ VLLFV 506_ TKKAN 511_ AEELA 516_ NNLKQ 521_ EGHNL 526_ GLLHG 531_ DMDQS 536_ ERNKV 541_ ISDFK 546_ KKDIP 551_ VLVAT 556_ DVAAR 561_ GLDIP 566_ SIKTV 571_ INYDV 576_ ARDID 581_ THTHR 586_ IGRTG 591_ RAGEK 596_ GVAYT 601_ LLTPK 606_ DSNFA 611_ GDLVR 616_ NLEGA 621_ NQHVS 626_ KELLD 631_ LAMQN 636_ AWFRK 641_ SRFKG 646_ GKGKK 651_ LNIGG 656_ GGLGY 661_ RERPG 666_ LGSEN 671_ MDRGN 676_ NNVMS 681_ NYEAY 686_ KPSTG 691_ AMGDR 696_ LTAMK 701_ AAFQS 706_ QYKSH 711_ FVAAS 716_ LSNQK 721_ AGSSA 726_ AGASG 731_ WTSAG 736_ SLNSV 741_ PTNSA 746_ QQGHN 751_ SPDSP 756_ VTSAA 761_ KGIPG 766_ FGNTG 771_ NISGA 776_ PVTYP 781_ SAGAQ 786_ GVNNT 791_ ASGNN 796_ SREGT 801_ GGSNG 806_ KRERY 811_ TENRG 816_ SSRHS 821_ HGETG 826_ NRHSD 831_ SPRHG 836_ DGGRH 841_ GDGYR 846_ HPESS 851_ SRHTD 856_ GHRHG 861_ ENRHG 866_ GSAGR 871_ HGENR 876_ GANDG 881_ RNGES 886_ RKEAF 891_ NRESK 896_ MEPKM 901_ EPKVD 906_ SSKMD 911_ KVDSK 916_ TDKTA 921_ DGFAV 926_ PEPPK 931_RKKSR
1: ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511)