TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
1_MGIGK 6_ SKINS 11_ CPLSL 16_ SWGKR 21_ HSVDT 26_ SPGYH 31_ ESDSK 36_ KSEDL 41_ SLCNV 46_ AEHSN 51_ TTEGP 56_ TGKQE 61_ GAQSV 66_ EEMFE 71_ EEAEE 76_ EVFLK 81_ FVILH 86_ AEDDT 91_ DEALR 96_ VQNLL 101_ QDDFG 106_ IKPGI 111_ IFAEM 116_ PCGRQ 121_ HLQNL 126_ DDAVN 131_ GSAWT 136_ ILLLT 141_ ENFLR 146_ DTWCN 151_ FQFYT 156_ SLMNS 161_ VNRQH 166_ KYNSV 171_ IPMRP 176_ LNNPL 181_ PRERT 186_ PFALQ 191_ TINAL 196_ EEESR 201_ GFPTQ 206_ VERIF 211_ QESVY 216_ KTQQT 221_ IWKET 226_RNMVQ
1: Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606)
2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes