E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)
1_MAWQV 6_ SLPEL 11_ EDRLQ 16_ CPICL 21_ EVFKE 26_ PLMLQ 31_ CGHSY 36_ CKGCL 41_ VSLSC 46_ HLDAE 51_ LRCPV 56_ CRQAV 61_ DGSSS 66_ LPNVS 71_ LARVI 76_ EALRL 81_ PGDPE 86_ PKVCV 91_ HHRNP 96_ LSLFC 101_ EKDQE 106_ LICGL 111_ CGLLG 116_ SHQHH 121_ PVTPV 126_ STVYS 131_ RMKEE 136_ LAALI 141_ SELKQ 146_ EQKKV 151_ DELIA 156_ KLVNN 161_ RTRIV 166_ NESDV 171_ FSWVI 176_ RREFQ 181_ ELHHL 186_ VDEEK 191_ ARCLE 196_ GIGGH 201_ TRGLV 206_ ASLDM 211_ QLEQA 216_ QGTRE 221_ RLAQA 226_ ECVLE 231_ QFGNE 236_ DHHKF 241_ IRKFH 246_ SMASR 251_ AEMPQ 256_ ARPLE 261_ GAFSP 266_ ISFKP 271_ GLHQA 276_ DIKLT 281_ VWKRL 286_ FRKVL 291_ PAPEP 296_ LKLDP 301_ ATAHP 306_ LLELS 311_ KGNTV 316_ VQCGL 321_ LAQRR 326_ ASQPE 331_ RFDYS 336_ TCVLA 341_ SRGFS 346_ CGRHY 351_ WEVVV 356_ GSKSD 361_ WRLGV 366_ IKGTA 371_ SRKGK 376_ LNRSP 381_ EHGVW 386_ LIGLK 391_ EGRVY 396_ EAFAC 401_ PRVPL 406_ PVAGH 411_ PHRIG 416_ LYLHY 421_ EQGEL 426_ TFFDA 431_ DRPDD 436_ LRPLY 441_ TFQAD 446_ FQGKL 451_ YPILD 456_ TCWHE 461_ RGSNS 466_ LPMVL 471_ PPPSG 476_ PGPLS 481_PEQPT
1: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)