E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)
1_MSRPG 6_ HGGLM 11_ PVNGL 16_ GFPPQ 21_ NVARV 26_ VVWEW 31_ LNEHS 36_ RWRPY 41_ TATVC 46_ HHIEN 51_ VLKED 56_ ARGSV 61_ VLGQV 66_ DAQLV 71_ PYIID 76_ LQSMH 81_ QFRQD 86_ TGTMR 91_ PVRRN 96_ FYDPS 101_ SAPGK 106_ GIVWE 111_ WENDG 116_ GAWTA 121_ YDMDI 126_ CITIQ 131_ NAYEK 136_ QHPWL 141_ DLSSL 146_ GFCYL 151_ IYFNS 156_ MSQMN 161_ RQTRR 166_ RRRLR 171_ RRLDL 176_ AYPLT 181_ VGSIP 186_ KSQSW 191_ PVGAS 196_ SGQPC 201_ SCQQC 206_ LLVNS 211_ TRAAS 216_ NAILA 221_ SQRRK 226_ APPAP 231_ PLPPP 236_ PPPGG 241_ PPGAL 246_ AVRPS 251_ ATFTG 256_ AALWA 261_ APAAG 266_ PAEPA 271_ PPPGA 276_ PPRSP 281_ GAPGG 286_ ARTPG 291_ QNNLN 296_ RPGPQ 301_ RTTSV 306_ SARAS 311_ IPPGV 316_ PALPV 321_ KNLNG 326_ TGPVH 331_ PALAG 336_ MTGIL 341_ LCAAG 346_ LPVCL 351_ TRAPK 356_ PILHP 361_ PPVSK 366_ SDVKP 371_ VPGVP 376_ GVCRK 381_ TKKKH 386_ LKKSK 391_ NPEDV 396_ VRRYM 401_ QKVKN 406_ PPDED 411_ CTICM 416_ ERLVT 421_ ASGYE 426_ GVLRH 431_ KGVRP 436_ ELVGR 441_ LGRCG 446_ HMYHL 451_ LCLVA 456_ MYSNG 461_ NKDGS 466_ LQCPT 471_ CKAIY 476_ GEKTG 481_ TQPPG 486_ KMEFH 491_ LIPHS 496_ LPGFP 501_ DTQTI 506_ RIVYD 511_ IPTGI 516_ QGPEH 521_ PNPGK 526_ KFTAR 531_ GFPRH 536_ CYLPN 541_ NEKGR 546_ KVLRL 551_ LITAW 556_ ERRLI 561_ FTIGT 566_ SNTTG 571_ ESDTV 576_ VWNEI 581_ HHKTE 586_ FGSNL 591_ TGHGY 596_ PDASY 601_ LDNVL 606_ AELTA 611_QGVSE
1: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1