Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) (G-protein coupled receptor PGR26)
1_MATPR 6_ GLGAL 11_ LLLLL 16_ LPTSG 21_ QEKPT 26_ EGPRN 31_ TCLGS 36_ NNMYD 41_ IFNLN 46_ DKALC 51_ FTKCR 56_ QSGSD 61_ SCNVE 66_ NLQRY 71_ WLNYE 76_ AHLMK 81_ EGLTQ 86_ KVNTP 91_ FLKAL 96_ VQNLS 101_ TNTAE 106_ DFYFS 111_ LEPSQ 116_ VPRQV 121_ MKDED 126_ KPPDR 131_ VRLPK 136_ SLFRS 141_ LPGNR 146_ SVVRL 151_ AVTIL 156_ DIGPG 161_ TLFKG 166_ PRLGL 171_ GDGSG 176_ VLNNR 181_ LVGLS 186_ VGQMH 191_ VTKLA 196_ EPLEI 201_ VFSHQ 206_ RPPPN 211_ MTLTC 216_ VFWDV 221_ TKGTT 226_ GDWSS 231_ EGCST 236_ EVRPE 241_ GTVCC 246_ CDHLT 251_ FFALL 256_ LRPTL 261_ DQSTV 266_ HILTR 271_ ISQAG 276_ CGVSM 281_ IFLAF 286_ TIILY 291_ AFLRL 296_ SRERF 301_ KSEDA 306_ PKIHV 311_ ALGGS 316_ LFLLN 321_ LAFLV 326_ NVGSG 331_ SKGSD 336_ AACWA 341_ RGAVF 346_ HYFLL 351_ CAFTW 356_ MGLEA 361_ FHLYL 366_ LAVRV 371_ FNTYF 376_ GHYFL 381_ KLSLV 386_ GWGLP 391_ ALMVI 396_ GTGSA 401_ NSYGL 406_ YTIRD 411_ RENRT 416_ SLELC 421_ WFREG 426_ TTMYA 431_ LYITV 436_ HGYFL 441_ ITFLF 446_ GMVVL 451_ ALVVW 456_ KIFTL 461_ SRATA 466_ VKERG 471_ KNRKK 476_ VLTLL 481_ GLSSL 486_ VGVTW 491_ GLAIF 496_ TPLGL 501_ STVYI 506_ FALFN 511_ SLQGV 516_ FICCW 521_ FTILY 526_ LPSQS 531_ TTVSS 536_ STARL 541_DQAHS
1: Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol (PubMed:33408414). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:33408414). ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:33408414). May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo (PubMed:22575658). Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity (PubMed:30559745, PubMed:36302784). Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes (PubMed:30559745). Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation (PubMed:36302784)