Gene name: LYPD6

Uniprot entry:

Q86Y78

Protein names:

Ly6/PLAUR domain-containing protein 6

Protein sequence:

1_MEPGP 6_ ALAWL 11_ LLLSL 16_ LADCL 21_ KAAQS 26_ RDFTV 31_ KDIIY 36_ LHPST 41_ TPYPG 46_ GFKCF 51_ TCEKA 56_ ADNYE 61_ CNRWA 66_ PDIYC 71_ PRETR 76_ YCYTQ 81_ HTMEV 86_ TGNSI 91_ SVTKR 96_ CVPLE 101_ ECLST 106_ GCRDS 111_ EHEGH 116_ KVCTS 121_ CCEGN 126_ ICNLP 131_ LPRNE 136_ TDATF 141_ ATTSP 146_ INQTN 151_ GHPRC 156_ MSVIV 161_ SCLWL 166_WLGLM

Protein annotations

Protein functions:

1: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity)