Probable peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)
1_MRPGG 6_ FLGAG 11_ QRLSR 16_ AMSRC 21_ VLEPR 26_ PPGKR 31_ WMVAG 36_ LGNPG 41_ LPGTR 46_ HSVGM 51_ AVLGQ 56_ LARRL 61_ GVAES 66_ WTRDR 71_ HCAAD 76_ LALAP 81_ LGDAQ 86_ LVLLR 91_ PRRLM 96_ NANGR 101_ SVARA 106_ AELFG 111_ LTAEE 116_ VYLVH 121_ DELDK 126_ PLGRL 131_ ALKLG 136_ GSARG 141_ HNGVR 146_ SCISC 151_ LNSNA 156_ MPRLR 161_ VGIGR 166_ PAHPE 171_ AVQAH 176_ VLGCF 181_ SPAEQ 186_ ELLPL 191_ LLDRA 196_ TDLIL 201_ DHIRE 206_RSQGP
1: Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831)