Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
1_MGPDR 6_ VTARE 11_ LCEND 16_ DLATS 21_ LVLDP 26_ YLGFR 31_ THKMN 36_ VSPVP 41_ PLRRQ 46_ QHLRS 51_ ALETF 56_ LRQRD 61_ LEAAY 66_ RALTL 71_ GGWTA 76_ RYFQS 81_ RGPRQ 86_ EAALK 91_ THVYR 96_ YLRAF 101_ LPESG 106_ FTILP 111_ CTRYS 116_ METNG 121_ AKIVS 126_ TRAWK 131_ KNEKL 136_ ELLVG 141_ CIAEL 146_ READE 151_ GLLRA 156_ GENDF 161_ SIMYS 166_ TRKRS 171_ AQLWL 176_ GPAAF 181_ INHDC 186_ KPNCK 191_ FVPAD 196_ GNAAC 201_ VKVLR 206_ DIEPG 211_ DEVTC 216_ FYGEG 221_ FFGEK 226_ NEHCE 231_ CHTCE 236_ RKGEG 241_ AFRTR 246_ PREPA 251_ LPPRP 256_ LDKYQ 261_ LRETK 266_ RRLQQ 271_ GLDSG 276_ SRQGL 281_ LGPRA 286_ CVHPS 291_ PLRRD 296_ PFCAA 301_ CQPLR 306_ LPACS 311_ ARPDT 316_ SPLWL 321_ QWLPQ 326_ PQPRV 331_ RPRKR 336_ RRPRP 341_ RRAPV 346_ LSTHH 351_ AARVS 356_ LHRWG 361_ GCGPH 366_ CRLRG 371_ EALVA 376_ LGQPP 381_ HARWA 386_ PQQDW 391_ HWARR 396_ YGLPY 401_ VVRVD 406_ LRRLA 411_ PAPPA 416_ TPAPA 421_ GTPGP 426_ ILIPK 431_ QALAF 436_ APFSP 441_ PKRLR 446_ LVVSH 451_ GSIDL 456_DVGGE
1: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)