ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)
1_MSQGV 6_ RRAGA 11_ GQGVA 16_ AAVQL 21_ LVTLS 26_ FLRSV 31_ VEAQV 36_ TGVLD 41_ DCLCD 46_ IDSID 51_ NFNTY 56_ KIFPK 61_ IKKLQ 66_ ERDYF 71_ RYYKV 76_ NLKRP 81_ CPFWA 86_ EDGHC 91_ SIKDC 96_ HVEPC 101_ PESKI 106_ PVGIK 111_ AGHSN 116_ KYLKM 121_ ANNTK 126_ ELEDC 131_ EQANK 136_ LGAIN 141_ STLSN 146_ QSKEA 151_ FIDWA 156_ RYDDS 161_ RDHFC 166_ ELDDE 171_ RSPAA 176_ QYVDL 181_ LLNPE 186_ RYTGY 191_ KGTSA 196_ WRVWN 201_ SIYEE 206_ NCFKP 211_ RSVYR 216_ PLNPL 221_ APSRG 226_ EDDGE 231_ SFYTW 236_ LEGLC 241_ LEKRV 246_ FYKLI 251_ SGLHA 256_ SINLH 261_ LCANY 266_ LLEET 271_ WGKPS 276_ WGPNI 281_ KEFKH 286_ RFDPV 291_ ETKGE 296_ GPRRL 301_ KNLYF 306_ LYLIE 311_ LRALS 316_ KVAPY 321_ FERSI 326_ VDLYT 331_ GNAEE 336_ DADTK 341_ TLLLN 346_ IFQDT 351_ KSFPM 356_ HFDEK 361_ SMFAG 366_ DKKGA 371_ KSLKE 376_ EFRLH 381_ FKNIS 386_ RIMDC 391_ VGCDK 396_ CRLWG 401_ KLQTQ 406_ GLGTA 411_ LKILF 416_ SEKEI 421_ QKLPE 426_ NSPSK 431_ GFQLT 436_ RQEIV 441_ ALLNA 446_ FGRLS 451_ TSIRD 456_ LQNFK 461_VLLQH
1: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis