Partner and localizer of BRCA2
1_MDEPP 6_ GKPLS 11_ CEEKE 16_ KLKEK 21_ LAFLK 26_ REYSK 31_ TLARL 36_ QRAQR 41_ AEKIK 46_ HSIKK 51_ TVEEQ 56_ DCLSQ 61_ QDLSP 66_ QLKHS 71_ EPKNK 76_ ICVYD 81_ KLHIK 86_ THLDE 91_ ETGEK 96_ TSITL 101_ DVGPE 106_ SFNPG 111_ DGPGG 116_ LPIQR 121_ TDDTQ 126_ EHFPH 131_ RVSDP 136_ SGEQK 141_ QKLPS 146_ RRKKQ 151_ QKRTF 156_ ISQER 161_ DCVFG 166_ TDSLR 171_ LSGKR 176_ LKEQE 181_ EISSK 186_ NPARS 191_ PVTEI 196_ RTHLL 201_ SLKSE 206_ LPDSP 211_ EPVTE 216_ INEDS 221_ VLIPP 226_ TAQPE 231_ KGVDT 236_ FLRRP 241_ NFTRA 246_ TTVPL 251_ QTLSD 256_ SGSSQ 261_ HLEHI 266_ PPKGS 271_ SELTT 276_ HDLKN 281_ IRFTS 286_ PVSLE 291_ AQGKK 296_ MTVST 301_ DNLLV 306_ NKAIS 311_ KSGQL 316_ PTSSN 321_ LEANI 326_ SCSLN 331_ ELTYN 336_ NLPAN 341_ ENQNL 346_ KEQNQ 351_ TEKSL 356_ KSPSD 361_ TLDGR 366_ NENLQ 371_ ESEIL 376_ SQPKS 381_ LSLEA 386_ TSPLS 391_ AEKHS 396_ CTVPE 401_ GLLFP 406_ AEYYV 411_ RTTRS 416_ MSNCQ 421_ RKVAV 426_ EAVIQ 431_ SHLDV 436_ KKKGF 441_ KNKNK 446_ DASKN 451_ LNLSN 456_ EETDQ 461_ SEIRM 466_ SGTCT 471_ GQPSS 476_ RTSQK 481_ LLSLT 486_ KVSSP 491_ AGPTE 496_ DNDLS 501_ RKAVA 506_ QAPGR 511_ RYTGK 516_ RKSAC 521_ TPASD 526_ HCEPL 531_ LPTSS 536_ LSIVN 541_ RSKEE 546_ VTSHK 551_ YQHEK 556_ LFIQV 561_ KGKKS 566_ RHQKE 571_ DSLSW 576_ SNSAY 581_ LSLDD 586_ DAFTA 591_ PFHRD 596_ GMLSL 601_ KQLLS 606_ FLSIT 611_ DFQLP 616_ DEDFG 621_ PLKLE 626_ KVKSC 631_ SEKPV 636_ EPFES 641_ KMFGE 646_ RHLKE 651_ GSCIF 656_ PEELS 661_ PKRMD 666_ TEMED 671_ LEEDL 676_ IVLPG 681_ KSHPK 686_ RPNSQ 691_ SQHTK 696_ TGLSS 701_ SILLY 706_ TPLNT 711_ VAPDD 716_ NDRPT 721_ TDMCS 726_ PAFPI 731_ LGTTP 736_ AFGPQ 741_ GSYEK 746_ ASTEV 751_ AGRTC 756_ CTPQL 761_ AHLKD 766_ SVCLA 771_ SDTKQ 776_ FDSSG 781_ SPAKP 786_ HTTLQ 791_ VSGRQ 796_ GQPTC 801_ DCDSV 806_ PPGTP 811_ PPIES 816_ FTFKE 821_ NQLCR 826_ NTCQE 831_ LHKHS 836_ VEQTE 841_ TAELP 846_ ASDSI 851_ NPGNL 856_ QLVSE 861_ LKNPS 866_ GSCSV 871_ DVSAM 876_ FWERA 881_ GCKEP 886_ CIITA 891_ CEDVV 896_ SLWKA 901_ LDAWQ 906_ WEKLY 911_ TWHFA 916_ EVPVL 921_ QIVPV 926_ PDVYN 931_ LVCVA 936_ LGNLE 941_ IREIR 946_ ALFCS 951_ SDDES 956_ EKQVL 961_ LKSGN 966_ IKAVL 971_ GLTKR 976_ RLVSS 981_ SGTLS 986_ DQQVE 991_ VMTFA 996_ EDGGG 1001_ KENQF 1006_ LMPPE 1011_ ETILT 1016_ FAEVQ 1021_ GMQEA 1026_ LLGTT 1031_ IMNNI 1036_ VIWNL 1041_ KTGQL 1046_ LKKMH 1051_ IDDSY 1056_ QASVC 1061_ HKAYS 1066_ EMGLL 1071_ FIVLS 1076_ HPCAK 1081_ ESESL 1086_ RSPVF 1091_ QLIVI 1096_ NPKTT 1101_ LSVGV 1106_ MLYCL 1111_ PPGQA 1116_ GRFLE 1121_ GDVKD 1126_ HCAAA 1131_ ILTSG 1136_ TIAIW 1141_ DLLLG 1146_ QCTAL 1151_ LPPVS 1156_ DQHWS 1161_ FVKWS 1166_ GTDSH 1171_ LLAGQ 1176_ KDGNI 1181_FVYHY
1: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656)