Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
1_MELLP 6_ LWLCL 11_ GFHFL 16_ TVGWR 21_ NRSGT 26_ ATAAS 31_ QGVCK 36_ LVGGA 41_ ADCRG 46_ QSLAS 51_ VPSSL 56_ PPHAR 61_ MLTLD 66_ ANPLK 71_ TLWNH 76_ SLQPY 81_ PLLES 86_ LSLHS 91_ CHLER 96_ ISRGA 101_ FQEQG 106_ HLRSL 111_ VLGDN 116_ CLSEN 121_ YEETA 126_ AALHA 131_ LPGLR 136_ RLDLS 141_ GNALT 146_ EDMAA 151_ LMLQN 156_ LSSLR 161_ SVSLA 166_ GNTIM 171_ RLDDS 176_ VFEGL 181_ ERLRE 186_ LDLQR 191_ NYIFE 196_ IEGGA 201_ FDGLA 206_ ELRHL 211_ NLAFN 216_ NLPCI 221_ VDFGL 226_ TRLRV 231_ LNVSY 236_ NVLEW 241_ FLATG 246_ GEAAF 251_ ELETL 256_ DLSHN 261_ QLLFF 266_ PLLPQ 271_ YSKLR 276_ TLLLR 281_ DNNMG 286_ FYRDL 291_ YNTSS 296_ PREMV 301_ AQFLL 306_ VDGNV 311_ TNITT 316_ VSLWE 321_ EFSSS 326_ DLADL 331_ RFLDM 336_ SQNQF 341_ QYLPD 346_ GFLRK 351_ MPSLS 356_ HLNLH 361_ QNCLM 366_ TLHIR 371_ EHEPP 376_ GALTE 381_ LDLSH 386_ NQLSE 391_ LHLAP 396_ GLASC 401_ LGSLR 406_ LFNLS 411_ SNQLL 416_ GVPPG 421_ LFANA 426_ RNITT 431_ LDMSH 436_ NQISL 441_ CPLPA 446_ ASDRV 451_ GPPSC 456_ VDFRN 461_ MASLR 466_ SLSLE 471_ GCGLG 476_ ALPDC 481_ PFQGT 486_ SLTYL 491_ DLSSN 496_ WGVLN 501_ GSLAP 506_ LQDVA 511_ PMLQV 516_ LSLRN 521_ MGLHS 526_ SFMAL 531_ DFSGF 536_ GNLRD 541_ LDLSG 546_ NCLTT 551_ FPRFG 556_ GSLAL 561_ ETLDL 566_ RRNSL 571_ TALPQ 576_ KAVSE 581_ QLSRG 586_ LRTIY 591_ LSQNP 596_ YDCCG 601_ VDGWG 606_ ALQHG 611_ QTVAD 616_ WAMVT 621_ CNLSS 626_ KIIRV 631_ TELPG 636_ GVPRD 641_ CKWER 646_ LDLGL 651_ LYLVL 656_ ILPSC 661_ LTLLV 666_ ACTVI 671_ VLTFK 676_ KPLLQ 681_ VIKSR 686_CHWSS
1: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260)