Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1)
1_MQAEA 6_ ADWFS 11_ SMPFQ 16_ KHVYY 21_ PLASG 26_ PEGPD 31_ VAVAA 36_ AAAGA 41_ ASMAC 46_ APPSA 51_ ASGPL 56_ PFFQF 61_ RPRLE 66_ SVDWR 71_ RLSAI 76_ DVDKV 81_ AGAVD 86_ VLTLQ 91_ ENIMN 96_ ITFCK 101_ LEDEK 106_ CPHCQ 111_ SGVDP 116_ VLLKL 121_ IRLAQ 126_ FTIEY 131_ LLHSQ 136_ EFLTS 141_ QLHTL 146_ EERLR 151_ LSHCD 156_ GEQSK 161_ KLLTK 166_ QAGEI 171_ KTLKE 176_ ECKRR 181_ KKMIS 186_ TQQLM 191_ IEAKA 196_ NYYQC 201_ HFCDK 206_ AFMNQ 211_ AFLQS 216_ HIQRR 221_ HTEEN 226_ SHFEY 231_ QKNAQ 236_ IEKLR 241_ SEIVV 246_ LKEEL 251_ QLTRS 256_ ELEAA 261_ HHASA 266_ VRFSK 271_ EYEMQ 276_ KTKEE 281_ DFLKL 286_ FDRWK 291_ EEEKE 296_ KLVDE 301_ MEKVK 306_ EMFMK 311_ EFKEL 316_ TSKNS 321_ ALEYQ 326_ LSEIQ 331_ KSNMQ 336_ IKSNI 341_ GTLKD 346_ AHEFK 351_ EDRSP 356_ YPQDF 361_ HNVMQ 366_ LLDSQ 371_ ESKWT 376_ ARVQA 381_ IHQEH 386_ KKEKG 391_ RLLSH 396_ IEKLR 401_ TSMID 406_ DLNAS 411_ NVFYK 416_ KRIEE 421_ LGQRL 426_ QEQNE 431_ LIITQ 436_ RQQIK 441_ DFTCN 446_ PLNSI 451_ SEPKG 456_ NPLAW 461_ QAFES 466_ QPAAP 471_ AVPMN 476_ APALH 481_ TLETK 486_ SSLPM 491_ VHEQA 496_ FSSHI 501_ LEPIE 506_ ELSEE 511_ EKGRE 516_ NEQKL 521_ NNNKM 526_ HLRKA 531_ LKSNS 536_ SLTKG 541_ LRTMV 546_ EQNLM 551_ EKLET 556_ LGINA 561_ DIRGI 566_ SSDQL 571_ HRVLK 576_ SVESE 581_ RHKQE 586_ REIPN 591_ FHQIR 596_ EFLEH 601_ QVSCK 606_ IEEKA 611_ LLSSD 616_ QCSVS 621_ QMDTL 626_ STGEV 631_ PKMIQ 636_ LPSKN 641_ RQLIR 646_ QKAVS 651_ TDRTS 656_ VPKIK 661_ KNVME 666_ DPFPR 671_ KSSTI 676_ TTPPF 681_ SSEEE 686_ QEDDD 691_ LIRAY 696_ ASPGP 701_ LPVPP 706_ PQNKG 711_ SFGKN 716_ TVKSD 721_ ADGTE 726_ GSEIE 731_ DTDDS 736_ PKPAG 741_ VAVKT 746_ PTEKV 751_ EKMFP 756_ HRKNV 761_ NKPVG 766_ GTNVP 771_ EMFIK 776_ KEELQ 781_ ELKCA 786_ DVEDE 791_ DWDIS 796_ SLEEE 801_ ISLGK 806_ KSGKE 811_ QKEPP 816_ PAKNE 821_ PHFAH 826_ VLNAW 831_ GAFNP 836_ KGPKG 841_ EGLQE 846_ NESST 851_ LKSSL 856_ VTVTD 861_WSDTS
1: Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954, PubMed:23955340, PubMed:27979967, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (By similarity). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967). It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (By similarity). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (By similarity). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257). Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289)