PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)
1_MDSDS 6_ CAAAF 11_ HPEEY 16_ SPSCK 21_ RRRTV 26_ EDFNK 31_ FCTFV 36_ LAYAG 41_ YIPYP 46_ KEELP 51_ LRSSP 56_ SPANS 61_ TAGTI 66_ DSDGW 71_ DAGFS 76_ DIASS 81_ VPLPV 86_ SDRCF 91_ SHLQP 96_ TLLQR 101_ AKPSN 106_ FLLDR 111_ KKTDK 116_ LKKKK 121_ KRKRR 126_ DSDAP 131_ GKEGY 136_ RGGLL 141_ KLEAA 146_ DPYVE 151_ TPTSP 156_ TLQDI 161_ PQAPS 166_ DPCSG 171_ WDSDT 176_ PSSGS 181_ CATVS 186_ PDQVK 191_ EIKTE 196_ GKRTI 201_ VRQGK 206_ QVVFR 211_ DEDST 216_ GNDED 221_ IMVDS 226_ DDDSW 231_ DLVTC 236_ FCMKP 241_ FAGRP 246_ MIECN 251_ ECHTW 256_ IHLSC 261_ AKIRK 266_ SNVPE 271_ VFVCQ 276_ KCRDS 281_ KFDIR 286_ RSNRS 291_RTGSR
1: Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response (PubMed:19638409). Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 (PubMed:23034801). Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis (PubMed:19638409). Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (PubMed:23034801). Essential for testicular stem-cell differentiation and sustained spermatogenesis (By similarity)