E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)
1_MLKSR 6_ LRMFL 11_ NELKL 16_ LVLTG 21_ GGRPR 26_ AEPQP 31_ RGGRG 36_ GGCGW 41_ APFAG 46_ CSTRD 51_ GDGDE 56_ EEYYG 61_ SEPRA 66_ RGLAG 71_ DKEPR 76_ AGPLP 81_ PPAPP 86_ LPPPG 91_ ALDAL 96_ SLSSS 101_ LDSGL 106_ RTPQC 111_ RICFQ 116_ GPEQG 121_ ELLSP 126_ CRCDG 131_ SVRCT 136_ HQPCL 141_ IRWIS 146_ ERGSW 151_ SCELC 156_ YFKYQ 161_ VLAIS 166_ TKNPL 171_ QWQAI 176_ SLTVI 181_ EKVQI 186_ AAIVL 191_ GSLFL 196_ VASIS 201_ WLIWS 206_ SLSPS 211_ AKWQR 216_ QDLLF 221_ QICYG 226_ MYGFM 231_ DVVCI 236_ GLIIH 241_ EGSSV 246_ YRIFK 251_ RWQAV 256_ NQQWK 261_ VLNYD 266_ KTKDI 271_ GGDAG 276_ GGTAG 281_ KSGPR 286_ NSRTG 291_ PTSGA 296_ TSRPP 301_ AAQRM 306_ RTLLP 311_ QRCGY 316_ TILHL 321_ LGQLR 326_ PPDAR 331_ SSSHS 336_ GREVV 341_MRVTT
1: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates