Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT)
1_MWYVS 6_ TRGVA 11_ PRVNF 16_ EGALF 21_ SGYAP 26_ DGGLF 31_ MPEEL 36_ PQLDR 41_ GTLCQ 46_ WSTLS 51_ YPGLV 56_ KELCA 61_ LFIGS 66_ ELLPK 71_ DELND 76_ LIDRA 81_ FSRFR 86_ HREVV 91_ HLSRL 96_ RNGLN 101_ VLELW 106_ HGVTY 111_ AFKDL 116_ SLSCT 121_ TQFLQ 126_ YFLEK 131_ REKHV 136_ TVVVG 141_ TSGDT 146_ GSAAI 151_ ESVQG 156_ AKNMD 161_ IIVLL 166_ PKGHC 171_ TKIQE 176_ LQMTT 181_ VLKQN 186_ VHVFG 191_ VEGNS 196_ DELDE 201_ PIKTV 206_ FADVA 211_ FVKKH 216_ NLMSL 221_ NSINW 226_ SRVLV 231_ QMAHH 236_ FFAYF 241_ QCTPS 246_ LDTHP 251_ LPLVE 256_ VVVPT 261_ GAAGN 266_ LAAGY 271_ IAQKI 276_ GLPIR 281_ LVVAV 286_ NRNDI 291_ IHRTV 296_ QQGDF 301_ SLSEA 306_ VKSTL 311_ ASAMD 316_ IQVPY 321_ NMERV 326_ FWLLS 331_ GSDSQ 336_ VTRAL 341_ MEQFE 346_ RTQSV 351_ NLPKE 356_ LHSKL 361_ SEAVT 366_ SVSVS 371_ DEAIT 376_ QTMGR 381_ CWDEN 386_ QYLLC 391_ PHSAV 396_ AVNYH 401_ YQQID 406_ RQQPS 411_ TPRCC 416_ LAPAS 421_ AAKFP 426_ EAVLA 431_ AGLTP 436_ ETPAE 441_ IVALE 446_ HKETR 451_ CTLMR 456_ RGDNW 461_ MLMLR 466_ DTIED 471_ LSRQW 476_RSHAL
1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
2: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions