Ankyrin repeat domain-containing protein 13B
1_MIPAN 6_ ASARK 11_ GPEGK 16_ YPLHY 21_ LVWHN 26_ RHREL 31_ EKEVR 36_ AGQVD 41_ IEQLD 46_ PRGRT 51_ PLHLA 56_ TTLGH 61_ LECAR 66_ VLLAH 71_ GADVG 76_ RENRS 81_ GWTVL 86_ QEAVS 91_ TRDLE 96_ LVQLV 101_ LRYRD 106_ YQRVV 111_ KRLAG 116_ IPVLL 121_ EKLRK 126_ AQDFY 131_ VEMKW 136_ EFTSW 141_ VPLVS 146_ KICPS 151_ DTYKV 156_ WKSGQ 161_ NLRVD 166_ TTLLG 171_ FDHMT 176_ WQRGN 181_ RSFVF 186_ RGQDT 191_ SAVVM 196_ EIDHD 201_ RRVVY 206_ TETLA 211_ LAGQD 216_ RELLL 221_ AAAQP 226_ TEEQV 231_ LSRLT 236_ APVVT 241_ TQLDT 246_ KNISF 251_ ERNKT 256_ GILGW 261_ RSEKT 266_ EMVNG 271_ YEAKV 276_ YGASN 281_ VELIT 286_ RTRTE 291_ HLSEQ 296_ HKGKV 301_ KGCKT 306_ PLQSF 311_ LGIAE 316_ QHGGP 321_ QNGTL 326_ ITQTL 331_ SQANP 336_ TAITA 341_ EEYFN 346_ PNFEL 351_ GNRDM 356_ GRPME 361_ LTTKT 366_ QKFKA 371_ KLWLC 376_ EEHPL 381_ SLCEQ 386_ VAPII 391_ DLMAV 396_ SNALF 401_ AKLRD 406_ FITLR 411_ LPPGF 416_ PVKIE 421_ IPIFH 426_ ILNAR 431_ ITFGN 436_ LNGCD 441_ EPVPS 446_ VRGSP 451_ SSETP 456_ SPGSD 461_ SSSVS 466_ SSSST 471_ TSCRG 476_ CEISP 481_ ALFEA 486_ PRGYS 491_ MMGGQ 496_ REAAT 501_ RDDDD 506_ DLLQF 511_ AIQQS 516_ LLEAG 521_ SEYDQ 526_ VTIWE 531_ ALTNS 536_ KPGTH 541_ PMSYE 546_ GRRQD 551_ RSAPP 556_ TPQRQ 561_ PAPPA 566_ SVPSP 571_ RPSSG 576_ PGSGG 581_ HVFRS 586_ YDEQL 591_ RLAME 596_ LSAQE 601_ QEERR 606_ RRARQ 611_ EEEEL 616_ ERILR 621_LSLTE
1: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane