Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)
1_MAGND 6_ CGALL 11_ DEELS 16_ SFFLN 21_ YLADT 26_ QGGGS 31_ GEEQL 36_ YADFP 41_ ELDLS 46_ QLDAS 51_ DFDSA 56_ TCFGE 61_ LQWCP 66_ ENSET 71_ EPNQY 76_ SPDDS 81_ ELFQI 86_ DSENE 91_ ALLAE 96_ LTKTL 101_ DDIPE 106_ DDVGL 111_ AAFPA 116_ LDGGD 121_ ALSCT 126_ SASPA 131_ PSSAP 136_ PSPAP 141_ EKPSA 146_ PAPEV 151_ DELSL 156_ LQKLL 161_ LATSY 166_ PTSSS 171_ DTQKE 176_ GTAWR 181_ QAGLR 186_ SKSQR 191_ PCVKA 196_ DSTQD 201_ KKAPM 206_ MQSQS 211_ RSCTE 216_ LHKHL 221_ TSAQC 226_ CLQDR 231_ GLQPP 236_ CLQSP 241_ RLPAK 246_ EDKEP 251_ GEDCP 256_ SPQPA 261_ PASPR 266_ DSLAL 271_ GRADP 276_ GAPVS 281_ QEDMQ 286_ AMVQL 291_ IRYMH 296_ TYCLP 301_ QRKLP 306_ PQTPE 311_ PLPKA 316_ CSNPS 321_ QQVRS 326_ RPWSR 331_ HHSKA 336_ SWAEF 341_ SILRE 346_ LLAQD 351_ VLCDV 356_ SKPYR 361_ LATPV 366_ YASLT 371_ PRSRP 376_ RPPKD 381_ SQASP 386_ GRPSS 391_ VEEVR 396_ IAASP 401_ KSTGP 406_ RPSLR 411_ PLRLE 416_ VKREV 421_ RRPAR 426_ LQQQE 431_ EEDEE 436_ EEEEE 441_ EEEEK 446_ EEEEE 451_ WGRKR 456_ PGRGL 461_ PWTKL 466_ GRKLE 471_ SSVCP 476_ VRRSR 481_ RLNPE 486_ LGPWL 491_ TFADE 496_ PLVPS 501_ EPQGA 506_ LPSLC 511_ LAPKA 516_ YDVER 521_ ELGSP 526_ TDEDS 531_ GQDQQ 536_ LLRGP 541_ QIPAL 546_ ESPCE 551_ SGCGD 556_ MDEDP 561_ SCPQL 566_ PPRDS 571_ PRCLM 576_ LALSQ 581_ SDPTF 586_ GKKSF 591_ EQTLT 596_ VELCG 601_ TAGLT 606_ PPTTP 611_ PYKPT 616_ EEDPF 621_ KPDIK 626_ HSLGK 631_ EIALS 636_ LPSPE 641_ GLSLK 646_ ATPGA 651_ AHKLP 656_ KKHPE 661_ RSELL 666_ SHLRH 671_ ATAQP 676_ ASQAG 681_ QKRPF 686_ SCSFG 691_ DHDYC 696_ QVLRP 701_ EGVLQ 706_ RKVLR 711_ SWEPS 716_ GVHLE 721_ DWPQQ 726_ GAPWA 731_ EAQAP 736_ GREED 741_ RSCDA 746_ GAPPK 751_ DSTLL 756_ RDHEI 761_ RASLT 766_ KHFGL 771_ LETAL 776_ EEEDL 781_ ASCKS 786_ PEYDT 791_ VFEDS 796_ SSSSG 801_ ESSFL 806_ PEEEE 811_ EEGEE 816_ EEEDD 821_ EEEDS 826_ GVSPT 831_ CSDHC 836_ PYQSP 841_ PSKAN 846_ RQLCS 851_ RSRSS 856_ SGSSP 861_ CHSWS 866_ PATRR 871_ NFRCE 876_ SRGPC 881_ SDRTP 886_ SIRHA 891_ RKRRE 896_ KAIGE 901_ GRVVY 906_ IQNLS 911_ SDMSS 916_ RELKR 921_ RFEVF 926_ GEIEE 931_ CEVLT 936_ RNRRG 941_ EKYGF 946_ ITYRC 951_ SEHAA 956_ LSLTK 961_ GAALR 966_ KRNEP 971_ SFQLS 976_ YGGLR 981_ HFCWP 986_ RYTDY 991_ DSNSE 996_ EALPA 1001_ SGKSK 1006_ YEAMD 1011_ FDSLL 1016_KEAQQ
1: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner