Ras-related protein Rab-43 (Ras-related protein Rab-41)
1_MAGPG 6_ PGPGD 11_ PDEQY 16_ DFLFK 21_ LVLVG 26_ DASVG 31_ KTCVV 36_ QRFKT 41_ GAFSE 46_ RQGST 51_ IGVDF 56_ TMKTL 61_ EIQGK 66_ RVKLQ 71_ IWDTA 76_ GQERF 81_ RTITQ 86_ SYYRS 91_ ANGAI 96_ LAYDI 101_ TKRSS 106_ FLSVP 111_ HWIED 116_ VRKYA 121_ GSNIV 126_ QLLIG 131_ NKSDL 136_ SELRE 141_ VSLAE 146_ AQSLA 151_ EHYDI 156_ LCAIE 161_ TSAKD 166_ SSNVE 171_ EAFLR 176_ VATEL 181_ IMRHG 186_ GPLFS 191_ EKSPD 196_ HIQLN 201_ SKDIG 206_EGWGC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis