E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
1_MSNSR 6_ NNRVM 11_ VEGVG 16_ ARVVR 21_ GPDWK 26_ WGKQD 31_ GGEGH 36_ VGTVR 41_ SFESP 46_ EEVVV 51_ VWDNG 56_ TAANY 61_ RCSGA 66_ YDLRI 71_ LDSAP 76_ TGIKH 81_ DGTMC 86_ DTCRQ 91_ QPIIG 96_ IRWKC 101_ AECTN 106_ YDLCT 111_ VCYHG 116_ DKHHL 121_ RHRFY 126_ RITTP 131_ GSERV 136_ LLESR 141_ RKSKK 146_ ITARG 151_ IFAGA 156_ RVVRG 161_ VDWQW 166_ EDQDG 171_ GNGRR 176_ GKVTE 181_ IQDWS 186_ ASSPH 191_ SAAYV 196_ LWDNG 201_ AKNLY 206_ RVGFE 211_ GMSDL 216_ KCVQD 221_ AKGGS 226_ FYRDH 231_ CPVLG 236_ EQNGN 241_ RNPGG 246_ LQIGD 251_ LVNID 256_ LDLEI 261_ VQSLQ 266_ HGHGG 271_ WTDGM 276_ FETLT 281_ TTGTV 286_ CGIDE 291_ DHDIV 296_ VQYPS 301_ GNRWT 306_ FNPAV 311_ LTKAN 316_ IVRSG 321_ DAAQG 326_ AEGGT 331_ SQFQV 336_ GDLVQ 341_ VCYDL 346_ ERIKL 351_ LQRGH 356_ GEWAE 361_ AMLPT 366_ LGKVG 371_ RVQQI 376_ YSDSD 381_ LKVEV 386_ CGTSW 391_ TYNPA 396_ AVSKV 401_ ASAGS 406_ AISNA 411_ SGERL 416_ SQLLK 421_ KLFET 426_ QESGD 431_ LNEEL 436_ VKAAA 441_ NGDVA 446_ KVEDL 451_ LKRPD 456_ VDVNG 461_ QCAGH 466_ TAMQA 471_ ASQNG 476_ HVDIL 481_ KLLLK 486_ QNVDV 491_ EAEDK 496_ DGDRA 501_ VHHAA 506_ FGDEG 511_ AVIEV 516_ LHRGS 521_ ADLNA 526_ RNKRR 531_ QTPLH 536_ IAVNK 541_ GHLQV 546_ VKTLL 551_ DFGCH 556_ PSLQD 561_ SEGDT 566_ PLHDA 571_ ISKKR 576_ DDILA 581_ VLLEA 586_ GADVT 591_ ITNNN 596_ GFNAL 601_ HHAAL 606_ RGNPS 611_ AMRVL 616_ LSKLP 621_ RPWIV 626_ DEKKD 631_ DGYTA 636_ LHLAA 641_ LNNHV 646_ EVAEL 651_ LVHQG 656_ NANLD 661_ IQNVN 666_ QQTAL 671_ HLAVE 676_ RQHTQ 681_ IVRLL 686_ VRAGA 691_ KLDIQ 696_ DKDGD 701_ TPLHE 706_ ALRHH 711_ TLSQL 716_ RQLQD 721_ MQDVG 726_ KVDAA 731_ WEPSK 736_ NTLIM 741_ GLGTQ 746_ GAEKK 751_ SAASI 756_ ACFLA 761_ ANGAD 766_ LSIRN 771_ KKGQS 776_ PLDLC 781_ PDPNL 786_ CKALA 791_ KCHKE 796_ KVSGQ 801_ VGSRS 806_ PSMIS 811_ NDSET 816_ LEECM 821_ VCSDM 826_ KRDTL 831_ FGPCG 836_ HIATC 841_ SLCSP 846_ RVKKC 851_ LICKE 856_ QVQSR 861_ TKIEE 866_ CVVCS 871_ DKKAA 876_ VLFQP 881_ CGHMC 886_ ACENC 891_ ANLMK 896_ KCVQC 901_ RAVVE 906_ RRVPF 911_ IMCCG 916_ GKSSE 921_ DATDD 926_ ISSGN 931_ IPVLQ 936_ KDKDN 941_ TNVNA 946_ DVQKL 951_ QQQLQ 956_ DIKEQ 961_ TMCPV 966_ CLDRL 971_ KNMIF 976_ LCGHG 981_ TCQLC 986_ GDRMS 991_ ECPIC 996_ RKAIE 1001_RRILL
1: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation
2: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection