Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1)
1_MFCPL 6_ KLILL 11_ PVLLD 16_ YSLGL 21_ NDLNV 26_ SPPEL 31_ TVHVG 36_ DSALM 41_ GCVFQ 46_ STEDK 51_ CIFKI 56_ DWTLS 61_ PGEHA 66_ KDEYV 71_ LYYYS 76_ NLSVP 81_ IGRFQ 86_ NRVHL 91_ MGDIL 96_ CNDGS 101_ LLLQD 106_ VQEAD 111_ QGTYI 116_ CEIRL 121_ KGESQ 126_ VFKKA 131_ VVLHV 136_ LPEEP 141_ KELMV 146_ HVGGL 151_ IQMGC 156_ VFQST 161_ EVKHV 166_ TKVEW 171_ IFSGR 176_ RAKEE 181_ IVFRY 186_ YHKLR 191_ MSVEY 196_ SQSWG 201_ HFQNR 206_ VNLVG 211_ DIFRN 216_ DGSIM 221_ LQGVR 226_ ESDGG 231_ NYTCS 236_ IHLGN 241_ LVFKK 246_ TIVLH 251_ VSPEE 256_ PRTLV 261_ TPAAL 266_ RPLVL 271_ GGNQL 276_ VIIVG 281_ IVCAT 286_ ILLLP 291_ VLILI 296_ VKKTC 301_ GNKSS 306_ VNSTV 311_ LVKNT 316_ KKTNP 321_ EIKEK 326_ PCHFE 331_ RCEGE 336_ KHIYS 341_ PIIVR 346_ EVIEE 351_ EEPSE 356_ KSEAT 361_ YMTMH 366_ PVWPS 371_ LRSDR 376_ NNSLE 381_ KKSGG 386_GMPKT
1: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR