Hermansky-Pudlak syndrome 6 protein (Ruby-eye protein homolog) (Ru)
1_MKRSG 6_ TLRLL 11_ SDLSA 16_ FGGAA 21_ RLREL 26_ VAGDS 31_ AVRVR 36_ GSPDG 41_ RHLLL 46_ LRPPG 51_ AVAPQ 56_ LLVAS 61_ RGPGA 66_ ELERA 71_ WPAGQ 76_ PSPLD 81_ AFFLP 86_ WPARP 91_ ALVLV 96_ WESGL 101_ AEVWG 106_ AGVGP 111_ GWRPL 116_ QSTEL 121_ CPGGG 126_ ARVVA 131_ VAALR 136_ GRLVW 141_ CEERQ 146_ ARAEG 151_ PSGSP 156_ AAAFS 161_ HCVCV 166_ RTLEP 171_ SGEAS 176_ TSLGR 181_ THVLL 186_ HHCPA 191_ FGLLA 196_ SCRQL 201_ FLVPT 206_ ATTWP 211_ GVAHV 216_ LLIWS 221_ PGKGK 226_ VMVAA 231_ PRLGL 236_ SYSKS 241_ LNPGR 246_ GDTWD 251_ FRTLL 256_ RGLPG 261_ LLSPR 266_ EPLAV 271_ HTWAP 276_ TPQGL 281_ LLLDF 286_ GGTVS 291_ LLQSH 296_ GGTRA 301_ VGTLQ 306_ EAPVG 311_ PWGSA 316_ ALGTF 321_ QGTLA 326_ CVLGS 331_ TLELL 336_ DMGSG 341_ QLLER 346_ KVLST 351_ DRVHL 356_ LEPPA 361_ PGMED 366_ EEELE 371_ TRGNL 376_ RLLSA 381_ LGLFC 386_ VGWEA 391_ PQGVE 396_ LPSAK 401_ DLVFE 406_ EACGY 411_ YQRRS 416_ LRGAQ 421_ LTPEE 426_ LRHSS 431_ TFRAP 436_ QALAS 441_ ILQGH 446_ LPPSA 451_ LLTML 456_ RTELR 461_ DYRGL 466_ EQLKA 471_ QLVAG 476_ DDEEA 481_ GWTEL 486_ AEQEV 491_ ARLLR 496_ TELIG 501_ DQLAQ 506_ LNTVF 511_ QALPT 516_ AAWGA 521_ TLRAL 526_ QLQLD 531_ GNGKL 536_ RSQAP 541_ PDVWK 546_ KVLGG 551_ ITAGK 556_ EPPNG 561_ ILPPF 566_ ELLCQ 571_ CLCQL 576_ EPRWL 581_ PPFVE 586_ LAQQQ 591_ GGPGW 596_ GAGGP 601_ GLPLY 606_ RRALA 611_ VLGEE 616_ GTRPE 621_ ALELE 626_ LLLSS 631_ GRPKA 636_ VLQAV 641_ GQLVQ 646_ KEQWD 651_ RALDA 656_ GLALG 661_ PSSPL 666_ LRSEI 671_ FKLLL 676_ AEFAQ 681_ HRRLD 686_ AHLPL 691_ LCRLC 696_ PPELA 701_ PAELL 706_ LLLRT 711_ YLPDE 716_ VGPPT 721_ PFPEP 726_ GAEPP 731_ LTVGL 736_ LKALL 741_ EQTGA 746_ QGWLS 751_ GPVLS 756_ PYEDI 761_ LWDPS 766_TPPPT
1: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619)