1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Testis-development protein NYD-SP27)
1_MEMRW 6_ FLSKI 11_ QDDFR 16_ GGKIN 21_ LEKTQ 26_ RLLEK 31_ LDIRC 36_ SYIHV 41_ KQIFK 46_ DNDRL 51_ KQGRI 56_ TIEEF 61_ RAIYR 66_ IITHR 71_ EEIIE 76_ IFNTY 81_ SENRK 86_ ILLAS 91_ NLAQF 96_ LTQEQ 101_ YAAEM 106_ SKAIA 111_ FEIIQ 116_ KYEPI 121_ EEVRK 126_ AHQMS 131_ LEGFT 136_ RYMDS 141_ RECLL 146_ FKNEC 151_ RKVYQ 156_ DMTHP 161_ LNDYF 166_ ISSSH 171_ NTYLV 176_ SDQLL 181_ GPSDL 186_ WGYVS 191_ ALVKG 196_ CRCLE 201_ IDCWD 206_ GAQNE 211_ PVVYH 216_ GYTLT 221_ SKLLF 226_ KTVIQ 231_ AIHKY 236_ AFMTS 241_ DYPVV 246_ LSLEN 251_ HCSTA 256_ QQEVM 261_ ADNLQ 266_ ATFGE 271_ SLLSD 276_ MLDDF 281_ PDTLP 286_ SPEAL 291_ KFKIL 296_ VKNKK 301_ IGTLK 306_ ETHER 311_ KGSDK 316_ RGDNQ 321_ DKETG 326_ VKKLP 331_ GVMLF 336_ KKKKT 341_ RKLKI 346_ ALALS 351_ DLVIY 356_ TKAEK 361_ FKSFQ 366_ HSRLY 371_ QQFNE 376_ NNSIG 381_ ETQAR 386_ KLSKL 391_ RVHEF 396_ IFHTR 401_ KFITR 406_ IYPKA 411_ TRADS 416_ SNFNP 421_ QEFWN 426_ IGCQM 431_ VALNF 436_ QTPGL 441_ PMDLQ 446_ NGKFL 451_ DNGGS 456_ GYILK 461_ PHFLR 466_ ESKSY 471_ FNPSN 476_ IKEGM 481_ PITLT 486_ IRLIS 491_ GIQLP 496_ LTHSS 501_ SNKGD 506_ SLVII 511_ EVFGV 516_ PNDQM 521_ KQQTR 526_ VIKKN 531_ AFSPR 536_ WNETF 541_ TFIIH 546_ VPELA 551_ LIRFV 556_ VEGQG 561_ LIAGN 566_ EFLGQ 571_ YTLPL 576_ LCMNK 581_ GYRRI 586_ PLFSR 591_ MGESL 596_ EPASL 601_FVYVW
1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function