Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)
1_MASQL 6_ QVFSP 11_ PSVSS 16_ SAFCS 21_ AKKLK 26_ IEPSG 31_ WDVSG 36_ QSSND 41_ KYYTH 46_ SKTLP 51_ ATQGQ 56_ ANSSH 61_ QVANF 66_ NIPAY 71_ DQGLL 76_ LPAPA 81_ VEHIV 86_ VTAAD 91_ SSGSA 96_ ATSTF 101_ QSSQT 106_ LTHRS 111_ NVSLL 116_ EPYQK 121_ CGLKR 126_ KSEEV 131_ DSNGS 136_ VQIIE 141_ EHPPL 146_ MLQNR 151_ TVVGA 156_ AATTT 161_ TVTTK 166_ SSSSS 171_ GEGDY 176_ QLVQH 181_ EILCS 186_ MTNSY 191_ EVLEF 196_ LGRGT 201_ FGQVA 206_ KCWKR 211_ STKEI 216_ VAIKI 221_ LKNHP 226_ SYARQ 231_ GQIEV 236_ SILSR 241_ LSSEN 246_ ADEYN 251_ FVRSY 256_ ECFQH 261_ KNHTC 266_ LVFEM 271_ LEQNL 276_ YDFLK 281_ QNKFS 286_ PLPLK 291_ YIRPI 296_ LQQVA 301_ TALMK 306_ LKSLG 311_ LIHAD 316_ LKPEN 321_ IMLVD 326_ PVRQP 331_ YRVKV 336_ IDFGS 341_ ASHVS 346_ KAVCS 351_ TYLQS 356_ RYYRA 361_ PEIIL 366_ GLPFC 371_ EAIDM 376_ WSLGC 381_ VIAEL 386_ FLGWP 391_ LYPGA 396_ SEYDQ 401_ IRYIS 406_ QTQGL 411_ PAEYL 416_ LSAGT 421_ KTTRF 426_ FNRDP 431_ NLGYP 436_ LWRLK 441_ TPEEH 446_ ELETG 451_ IKSKE 456_ ARKYI 461_ FNCLD 466_ DMAQV 471_ NMSTD 476_ LEGTD 481_ MLAEK 486_ ADRRE 491_ YIDLL 496_ KKMLT 501_ IDADK 506_ RITPL 511_ KTLNH 516_ QFVTM 521_ THLLD 526_ FPHSN 531_ HVKSC 536_ FQNME 541_ ICKRR 546_ VHMYD 551_ TVSQI 556_ KSPFT 561_ THVAP 566_ NTSTN 571_ LTMSF 576_ SNQLN 581_ TVHNQ 586_ ASVLA 591_ SSSTA 596_ AAATL 601_ SLANS 606_ DVSLL 611_ NYQSA 616_ LYPSS 621_ AAPVP 626_ GVAQQ 631_ GVSLQ 636_ PGTTQ 641_ ICTQT 646_ DPFQQ 651_ TFIVC 656_ PPAFQ 661_ TGLQA 666_ TTKHS 671_ GFPVR 676_ MDNAV 681_ PIVPQ 686_ APAAQ 691_ PLQIQ 696_ SGVLT 701_ QGSCT 706_ PLMVA 711_ TLHPQ 716_ VATIT 721_ PQYAV 726_ PFTLS 731_ CAAGR 736_ PALVE 741_ QTAAV 746_ LQAWP 751_ GGTQQ 756_ ILLPS 761_ TWQQL 766_ PGVAL 771_ HNSVQ 776_ PTAMI 781_ PEAMG 786_ SGQQL 791_ ADWRN 796_ AHSHG 801_ NQYST 806_ IMQQP 811_ SLLTN 816_ HVTLA 821_ TAQPL 826_ NVGVA 831_ HVVRQ 836_ QQSSS 841_ LPSKK 846_ NKQSA 851_ PVSSK 856_ SSLDV 861_ LPSQV 866_ YSLVG 871_ SSPLR 876_ TTSSY 881_ NSLVP 886_ VQDQH 891_ QPIII 896_ PDTPS 901_ PPVSV 906_ ITIRS 911_ DTDEE 916_ EDNKY 921_ KPSSS 926_ GLKPR 931_ SNVIS 936_ YVTVN 941_ DSPDS 946_ DSSLS 951_ SPYST 956_ DTLSA 961_ LRGNS 966_ GSVLE 971_ GPGRV 976_ VADGT 981_ GTRTI 986_ IVPPL 991_ KTQLG 996_ DCTVA 1001_ TQASG 1006_ LLSNK 1011_ TKPVA 1016_ SVSGQ 1021_ SSGCC 1026_ ITPTG 1031_ YRAQR 1036_ GGTSA 1041_ AQPLN 1046_ LSQNQ 1051_ QSSAA 1056_ PTSQE 1061_ RSSNP 1066_ APRRQ 1071_ QAFVA 1076_ PLSQA 1081_ PYTFQ 1086_ HGSPL 1091_ HSTGH 1096_ PHLAP 1101_ APAHL 1106_ PSQAH 1111_ LYTYA 1116_ APTSA 1121_ AALGS 1126_ TSSIA 1131_ HLFSP 1136_ QGSSR 1141_ HAAAY 1146_ TTHPS 1151_ TLVHQ 1156_ VPVSV 1161_ GPSLL 1166_ TSASV 1171_ APAQY 1176_ QHQFA 1181_ TQSYI 1186_ GSSRG 1191_ STIYT 1196_ GYPLS 1201_PTKIS
1: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171)