Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
1_MKPGC 6_ AAGSP 11_ GNEWI 16_ FFSTD 21_ EITTR 26_ YRNTM 31_ SNGGL 36_ QRSVI 41_ LSALI 46_ LLRAV 51_ TGFSG 56_ DGRAI 61_ WSKNP 66_ NFTPV 71_ NESQL 76_ FLYDT 81_ FPKNF 86_ FWGIG 91_ TGALQ 96_ VEGSW 101_ KKDGK 106_ GPSIW 111_ DHFIH 116_ THLKN 121_ VSSTN 126_ GSSDS 131_ YIFLE 136_ KDLSA 141_ LDFIG 146_ VSFYQ 151_ FSISW 156_ PRLFP 161_ DGIVT 166_ VANAK 171_ GLQYY 176_ STLLD 181_ ALVLR 186_ NIEPI 191_ VTLYH 196_ WDLPL 201_ ALQEK 206_ YGGWK 211_ NDTII 216_ DIFND 221_ YATYC 226_ FQMFG 231_ DRVKY 236_ WITIH 241_ NPYLV 246_ AWHGY 251_ GTGMH 256_ APGEK 261_ GNLAA 266_ VYTVG 271_ HNLIK 276_ AHSKV 281_ WHNYN 286_ THFRP 291_ HQKGW 296_ LSITL 301_ GSHWI 306_ EPNRS 311_ ENTMD 316_ IFKCQ 321_ QSMVS 326_ VLGWF 331_ ANPIH 336_ GDGDY 341_ PEGMR 346_ KKLFS 351_ VLPIF 356_ SEAEK 361_ HEMRG 366_ TADFF 371_ AFSFG 376_ PNNFK 381_ PLNTM 386_ AKMGQ 391_ NVSLN 396_ LREAL 401_ NWIKL 406_ EYNNP 411_ RILIA 416_ ENGWF 421_ TDSRV 426_ KTEDT 431_ TAIYM 436_ MKNFL 441_ SQVLQ 446_ AIRLD 451_ EIRVF 456_ GYTAW 461_ SLLDG 466_ FEWQD 471_ AYTIR 476_ RGLFY 481_ VDFNS 486_ KQKER 491_ KPKSS 496_ AHYYK 501_ QIIRE 506_ NGFSL 511_ KESTP 516_ DVQGQ 521_ FPCDF 526_ SWGVT 531_ ESVLK 536_ PESVA 541_ SSPQF 546_ SDPHL 551_ YVWNA 556_ TGNRL 561_ LHRVE 566_ GVRLK 571_ TRPAQ 576_ CTDFV 581_ NIKKQ 586_ LEMLA 591_ RMKVT 596_ HYRFA 601_ LDWAS 606_ VLPTG 611_ NLSAV 616_ NRQAL 621_ RYYRC 626_ VVSEG 631_ LKLGI 636_ SAMVT 641_ LYYPT 646_ HAHLG 651_ LPEPL 656_ LHADG 661_ WLNPS 666_ TAEAF 671_ QAYAG 676_ LCFQE 681_ LGDLV 686_ KLWIT 691_ INEPN 696_ RLSDI 701_ YNRSG 706_ NDTYG 711_ AAHNL 716_ LVAHA 721_ LAWRL 726_ YDRQF 731_ RPSQR 736_ GAVSL 741_ SLHAD 746_ WAEPA 751_ NPYAD 756_ SHWRA 761_ AERFL 766_ QFEIA 771_ WFAEP 776_ LFKTG 781_ DYPAA 786_ MREYI 791_ ASKHR 796_ RGLSS 801_ SALPR 806_ LTEAE 811_ RRLLK 816_ GTVDF 821_ CALNH 826_ FTTRF 831_ VMHEQ 836_ LAGSR 841_ YDSDR 846_ DIQFL 851_ QDITR 856_ LSSPT 861_ RLAVI 866_ PWGVR 871_ KLLRW 876_ VRRNY 881_ GDMDI 886_ YITAS 891_ GIDDQ 896_ ALEDD 901_ RLRKY 906_ YLGKY 911_ LQEVL 916_ KAYLI 921_ DKVRI 926_ KGYYA 931_ FKLAE 936_ EKSKP 941_ RFGFF 946_ TSDFK 951_ AKSSI 956_ QFYNK 961_ VISSR 966_ GFPFE 971_ NSSSR 976_ CSQTQ 981_ ENTEC 986_ TVCLF 991_ LVQKK 996_ PLIFL 1001_ GCCFF 1006_ STLVL 1011_ LLSIA 1016_ IFQRQ 1021_ KRRKF 1026_ WKAKN 1031_ LQHIP 1036_LKKGK
1: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity)