DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)
1_MAKVP 6_ ELEDT 11_ FLQAQ 16_ PAPQL 21_ SPGIQ 26_ EDCCV 31_ QLLGK 36_ GLLVY 41_ PEETV 46_ YLAAE 51_ GQPGG 56_ EQGGG 61_ EKGED 66_ PELPG 71_ AVKSE 76_ MHLNN 81_ GNFSS 86_ EEEDA 91_ DNHDS 96_ KTKAA 101_ DQYLS 106_ QKKTI 111_ TQIVK 116_ DKKKQ 121_ TQLTL 126_ QWLEE 131_ NYIVC 136_ EGVCL 141_ PRCIL 146_ YAHYL 151_ DFCRK 156_ EKLEP 161_ ACAAT 166_ FGKTI 171_ RQKFP 176_ LLTTR 181_ RLGTR 186_ GHSKY 191_ HYYGI 196_ GIKES 201_ SAYYH 206_ SVYSG 211_ KGLTR 216_ FSGSK 221_ LKNEG 226_ GFTRK 231_ YSLSS 236_ KTGTL 241_ LPEFP 246_ SAQHL 251_ VYQGC 256_ ISKDK 261_ VDTLI 266_ MMYKT 271_ HCQCI 276_ LDNAI 281_ NGNFE 286_ EIQHF 291_ LLHFW 296_ QGMPD 301_ HLLPL 306_ LENPV 311_ IIDIF 316_ CVCDS 321_ ILYKV 326_ LTDVL 331_ IPATM 336_ QEMPE 341_ SLLAD 346_ IRNFA 351_ KNWEQ 356_ WVVSS 361_ LENLP 366_ EALTD 371_ KKIPI 376_ VRRFV 381_ SSLKR 386_ QTSFL 391_ HLAQI 396_ ARPAL 401_ FDQHV 406_ VNSMV 411_ SDIER 416_ VDLNS 421_ IGSQA 426_ LLTIS 431_ GSTDT 436_ ESGIY 441_ TEHDS 446_ ITVFQ 451_ ELKDL 456_ LKKNA 461_ TVEAF 466_ IEWLD 471_ TVVEQ 476_ RVIKT 481_ SKQNG 486_ RSLKK 491_ RAQDF 496_ LLKWS 501_ FFGAR 506_ VMHNL 511_ TLNNA 516_ SSFGS 521_ FHLIR 526_ MLLDE 531_ YILLA 536_ METQF 541_ NNDKE 546_ QELQN 551_ LLDKY 556_ MKNSD 561_ ASKAA 566_ FTASP 571_ SSCFL 576_ ANRNK 581_ GSMVS 586_ SDAVK 591_ NESHV 596_ ETTYL 601_ PLPSS 606_ QPGGL 611_ GPALH 616_ QFPAG 621_ NTDNM 626_ PLTGQ 631_ MELSQ 636_ IAGHL 641_ MTPPI 646_ SPAMA 651_ SRGSV 656_ INQGP 661_ MAGRP 666_ PSVGP 671_ VLSAP 676_ SHCST 681_ YPEPI 686_ YPTLP 691_ QANHD 696_ FYSTS 701_ SNYQT 706_ VFRAQ 711_ PHSTS 716_ GLYPH 721_ HTEHG 726_ RCMAW 731_ TEQQL 736_ SRDFF 741_ SGSCA 746_ GSPYN 751_ SRPPS 756_ SYGPS 761_ LQAQD 766_ SHNMQ 771_ FLNTG 776_ SFNFL 781_ SNTGA 786_ ASCQG 791_ ATLPP 796_ NSPNG 801_ YYGSN 806_ INYPE 811_ SHRLG 816_ SMVNQ 821_ HVSVI 826_ SSIRS 831_ LPPYS 836_ DIHDP 841_ LNILD 846_ DSGRK 851_ QTSSF 856_ YTDTS 861_ SPVAC 866_ RTPVL 871_ ASSLQ 876_ TPIPS 881_ SSSQC 886_ MYGTS 891_ NQYPA 896_ QETLD 901_ SHGTS 906_ SREMV 911_ SSLPP 916_ INTVF 921_MGTAA
1: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100)