Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)
1_MAAAW 6_ TVVLV 11_ TLVLG 16_ LAVAG 21_ PVPTS 26_ KPTTT 31_ GKGCH 36_ IGRFK 41_ SLSPQ 46_ ELASF 51_ KKARD 56_ ALEES 61_ LKLKN 66_ WSCSS 71_ PVFPG 76_ NWDLR 81_ LLQVR 86_ ERPVA 91_ LEAEL 96_ ALTLK 101_ VLEAA 106_ AGPAL 111_ EDVLD 116_ QPLHT 121_ LHHIL 126_ SQLQA 131_ CIQPQ 136_ PTAGP 141_ RPRGR 146_ LHHWL 151_ HRLQE 156_ APKKE 161_ SAGCL 166_ EASVT 171_ FNLFR 176_ LLTRD 181_ LKYVA 186_ DGNLC 191_LRTST
1: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression