Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
1_MAGPE 6_ RWGPL 11_ LLCLL 16_ QAAPG 21_ RPRLA 26_ PPQNV 31_ TLLSQ 36_ NFSVY 41_ LTWLP 46_ GLGNP 51_ QDVTY 56_ FVAYQ 61_ SSPTR 66_ RRWRE 71_ VEECA 76_ GTKEL 81_ LCSMM 86_ CLKKQ 91_ DLYNK 96_ FKGRV 101_ RTVSP 106_ SSKSP 111_ WVESE 116_ YLDYL 121_ FEVEP 126_ APPVL 131_ VLTQT 136_ EEILS 141_ ANATY 146_ QLPPC 151_ MPPLD 156_ LKYEV 161_ AFWKE 166_ GAGNK 171_ TLFPV 176_ TPHGQ 181_ PVQIT 186_ LQPAA 191_ SEHHC 196_ LSART 201_ IYTFS 206_ VPKYS 211_ KFSKP 216_ TCFLL 221_ EVPEA 226_ NWAFL 231_ VLPSL 236_ LILLL 241_ VIAAG 246_ GVIWK 251_ TLMGN 256_ PWFQR 261_ AKMPR 266_ ALDFS 271_ GHTHP 276_ VATFQ 281_ PSRPE 286_ SVNDL 291_ FLCPQ 296_ KELTR 301_ GVRPT 306_ PRVRA 311_ PATQQ 316_ TRWKK 321_ DLAED 326_ EEEED 331_ EEDTE 336_ DGVSF 341_ QPYIE 346_ PPSFL 351_ GQEHQ 356_ APGHS 361_ EAGGV 366_ DSGRP 371_ RAPLV 376_ PSEGS 381_ SAWDS 386_ SDRSW 391_ ASTVD 396_ SSWDR 401_ AGSSG 406_ YLAEK 411_ GPGQG 416_ PGGDG 421_ HQESL 426_ PPPEF 431_ SKDSG 436_ FLEEL 441_ PEDNL 446_ SSWAT 451_ WGTLP 456_ PEPNL 461_ VPGGP 466_ PVSLQ 471_ TLTFC 476_ WESSP 481_ EEEEE 486_ ARESE 491_ IEDSD 496_ AGSWG 501_ AESTQ 506_ RTEDR 511_GRTLG
1: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium