m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)
1_METKR 6_ VEIPG 11_ SVLDD 16_ LCSRF 21_ ILHIP 26_ SEERD 31_ NAIRV 36_ CFQIE 41_ LAHWF 46_ YLDFY 51_ MQNTP 56_ GLPQC 61_ GIRDF 66_ AKAVF 71_ SHCPF 76_ LLPQG 81_ EDVEK 86_ VLDEW 91_ KEYKM 96_ GVPTY 101_ GAIIL 106_ DETLE 111_ NVLLV 116_ QGYLA 121_ KSGWG 126_ FPKGK 131_ VNKEE 136_ APHDC 141_ AAREV 146_ FEETG 151_ FDIKD 156_ YICKD 161_ DYIEL 166_ RINDQ 171_ LARLY 176_ IIPGI 181_ PKDTK 186_ FNPKT 191_ RREIR 196_ NIEWF 201_ SIEKL 206_ PCHRN 211_ DMTPK 216_ SKLGL 221_ APNKF 226_ FMAIP 231_ FIRPL 236_ RDWLS 241_ RRFGD 246_ SSDSD 251_ NGFSS 256_ TGSTP 261_ AKPTV 266_ EKLSR 271_ TKFRH 276_ SQQLF 281_ PDGSP 286_ GDQWV 291_ KHRQP 296_ LQQKP 301_ YNNHS 306_ EMSDL 311_ LKGKN 316_ QSMRG 321_ NGRKQ 326_ YQDSP 331_ NQKKR 336_ TNGLQ 341_ PAKQQ 346_ NSLMK 351_ CEKKL 356_ HPRKL 361_ QDNFE 366_ TDAVY 371_ DLPSS 376_ SEDQL 381_ LEHAE 386_ GQPVA 391_ CNGHC 396_ KFPFS 401_ SRAFL 406_ SFKFD 411_HNAIM
1: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)