Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2)
1_MLLPR 6_ SVSSE 11_ RAPGV 16_ PEPEE 21_ LWEAE 26_ MERLR 31_ GSGTP 36_ VRGLP 41_ YAMMD 46_ KRLIW 51_ QLREP 56_ AGVQT 61_ LRWQR 66_ WQRRR 71_ QTVER 76_ RLREA 81_ AQRLA 86_ RGLGL 91_ WEGAL 96_ YEIGG 101_ LFGTG 106_ IRSYF 111_ TFLRF 116_ LLLLN 121_ LLSLL 126_ LTASF 131_ VLLPL 136_ VWLRP 141_ PDPGP 146_ TLNLT 151_ LQCPG 156_ SRQSP 161_ PGVLR 166_ FHNQL 171_ WHVLT 176_ GRAFT 181_ NTYLF 186_ YGAYR 191_ VGPES 196_ SSVYS 201_ IRLAY 206_ LLSPL 211_ ACLLL 216_ CFCGT 221_ LRRMV 226_ KGLPQ 231_ KTLLG 236_ QGYQA 241_ PLSAK 246_ VFSSW 251_ DFCIR 256_ VQEAA 261_ TIKKH 266_ EISNE 271_ FKVEL 276_ EEGRR 281_ FQLMQ 286_ QQTRA 291_ QTACR 296_ LLSYL 301_ RVNVL 306_ NGLLV 311_ VGAIS 316_ AIFWA 321_ TKYSQ 326_ DNKEE 331_ SLFLL 336_ LQYLP 341_ PGVIA 346_ LVNFL 351_ GPLLF 356_ TFLVQ 361_ LENYP 366_ PNTEV 371_ NLTLI 376_ WCVVL 381_ KLASL 386_ GMFSV 391_ SLGQT 396_ ILCIG 401_ RDKSS 406_ CESYG 411_ YNVCD 416_ YQCWE 421_ NSVGE 426_ ELYKL 431_ SIFNF 436_ LLTVA 441_ FAFLV 446_ TLPRR 451_ LLVDR 456_ FSGRF 461_ WAWLE 466_ REEFL 471_ VPKNV 476_ LDIVA 481_ GQTVT 486_ WMGLF 491_ YCPLL 496_ PLLNS 501_ VFLFL 506_ TFYIK 511_ KYTLL 516_ KNSRA 521_ SSRPF 526_ RASSS 531_ TFFFQ 536_ LVLLL 541_ GLLLA 546_ AVPLG 551_ YVVSS 556_ IHSSW 561_ DCGLF 566_ TNYSA 571_ PWQVV 576_ PELVA 581_ LGLPP 586_ IGQRA 591_ LHYLG 596_ SHAFS 601_ FPLLI 606_ MLSLV 611_ LTVCV 616_ SQTQA 621_ NARAI 626_ HRLRK 631_ QLVWQ 636_ VQEKW 641_ HLVED 646_ LSRLL 651_ PEPGP 656_ SDSPG 661_ PKYPA 666_ SQASR 671_ PQSFC 676_ PGCPC 681_ PGSPG 686_ HQAPR 691_ PGPSV 696_ VDAAG 701_ LRSPC 706_ PGQHG 711_ APASA 716_ RRFRF 721_PSGAE
1: Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285)