Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2)
1_MLLLF 6_ HSKRM 11_ PVAEA 16_ PQVAG 21_ GQGDG 26_ GDGEE 31_ AEPEG 36_ MFKAC 41_ EDSKR 46_ KARGY 51_ LRLVP 56_ LFVLL 61_ ALLVL 66_ ASAGV 71_ LLWYF 76_ LGYKA 81_ EVMVS 86_ QVYSG 91_ SLRVL 96_ NRHFS 101_ QDLTR 106_ RESSA 111_ FRSET 116_ AKAQK 121_ MLKEL 126_ ITSTR 131_ LGTYY 136_ NSSSV 141_ YSFGE 146_ GPLTC 151_ FFWFI 156_ LQIPE 161_ HRRLM 166_ LSPEV 171_ VQALL 176_ VEELL 181_ STVNS 186_ SAAVP 191_ YRAEY 196_ EVDPE 201_ GLVIL 206_ EASVK 211_ DIAAL 216_ NSTLG 221_ CYRYS 226_ YVGQG 231_ QVLRL 236_ KGPDH 241_ LASSC 246_ LWHLQ 251_ GPKDL 256_ MLKLR 261_ LEWTL 266_ AECRD 271_ RLAMY 276_ DVAGP 281_ LEKRL 286_ ITSVY 291_ GCSRQ 296_ EPVVE 301_ VLASG 306_ AIMAV 311_ VWKKG 316_ LHSYY 321_ DPFVL 326_ SVQPV 331_ VFQAC 336_ EVNLT 341_ LDNRL 346_ DSQGV 351_ LSTPY 356_ FPSYY 361_ SPQTH 366_ CSWHL 371_ TVPSL 376_ DYGLA 381_ LWFDA 386_ YALRR 391_ QKYDL 396_ PCTQG 401_ QWTIQ 406_ NRRLC 411_ GLRIL 416_ QPYAE 421_ RIPVV 426_ ATAGI 431_ TINFT 436_ SQISL 441_ TGPGV 446_ RVHYG 451_ LYNQS 456_ DPCPG 461_ EFLCS 466_ VNGLC 471_ VPACD 476_ GVKDC 481_ PNGLD 486_ ERNCV 491_ CRATF 496_ QCKED 501_ STCIS 506_ LPKVC 511_ DGQPD 516_ CLNGS 521_ DEEQC 526_ QEGVP 531_ CGTFT 536_ FQCED 541_ RSCVK 546_ KPNPQ 551_ CDGRP 556_ DCRDG 561_ SDEEH 566_ CDCGL 571_ QGPSS 576_ RIVGG 581_ AVSSE 586_ GEWPW 591_ QASLQ 596_ VRGRH 601_ ICGGA 606_ LIADR 611_ WVITA 616_ AHCFQ 621_ EDSMA 626_ STVLW 631_ TVFLG 636_ KVWQN 641_ SRWPG 646_ EVSFK 651_ VSRLL 656_ LHPYH 661_ EEDSH 666_ DYDVA 671_ LLQLD 676_ HPVVR 681_ SAAVR 686_ PVCLP 691_ ARSHF 696_ FEPGL 701_ HCWIT 706_ GWGAL 711_ REGGP 716_ ISNAL 721_ QKVDV 726_ QLIPQ 731_ DLCSE 736_ VYRYQ 741_ VTPRM 746_ LCAGY 751_ RKGKK 756_ DACQG 761_ DSGGP 766_ LVCKA 771_ LSGRW 776_ FLAGL 781_ VSWGL 786_ GCGRP 791_ NYFGV 796_ YTRIT 801_ GVISW 806_IQQVV
1: Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18408718, PubMed:18976966, PubMed:25156943)