Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK)
1_MAREN 6_ GESSS 11_ SWKKQ 16_ AEDIK 21_ KIFEF 26_ KETLG 31_ TGAFS 36_ EVVLA 41_ EEKAT 46_ GKLFA 51_ VKCIP 56_ KKALK 61_ GKESS 66_ IENEI 71_ AVLRK 76_ IKHEN 81_ IVALE 86_ DIYES 91_ PNHLY 96_ LVMQL 101_ VSGGE 106_ LFDRI 111_ VEKGF 116_ YTEKD 121_ ASTLI 126_ RQVLD 131_ AVYYL 136_ HRMGI 141_ VHRDL 146_ KPENL 151_ LYYSQ 156_ DEESK 161_ IMISD 166_ FGLSK 171_ MEGKG 176_ DVMST 181_ ACGTP 186_ GYVAP 191_ EVLAQ 196_ KPYSK 201_ AVDCW 206_ SIGVI 211_ AYILL 216_ CGYPP 221_ FYDEN 226_ DSKLF 231_ EQILK 236_ AEYEF 241_ DSPYW 246_ DDISD 251_ SAKDF 256_ IRNLM 261_ EKDPN 266_ KRYTC 271_ EQAAR 276_ HPWIA 281_ GDTAL 286_ NKNIH 291_ ESVSA 296_ QIRKN 301_ FAKSK 306_ WRQAF 311_ NATAV 316_ VRHMR 321_ KLHLG 326_ SSLDS 331_ SNASV 336_ SSSLS 341_ LASQK 346_ DCLAP 351_ STLCS 356_ FISSS 361_ SGVSG 366_ VGAER 371_ RPRPT 376_TVTAV
1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta