Ceramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297)
1_MFWTF 6_ KEWFW 11_ LERFW 16_ LPPTI 21_ KWSDL 26_ EDHDG 31_ LVFVK 36_ PSHLY 41_ VTIPY 46_ AFLLL 51_ IIRRV 56_ FEKFV 61_ ASPLA 66_ KSFGI 71_ KETVR 76_ KVTPN 81_ TVLEN 86_ FFKHS 91_ TRQPL 96_ QTDIY 101_ GLAKK 106_ CNLTE 111_ RQVER 116_ WFRSR 121_ RNQER 126_ PSRLK 131_ KFQEA 136_ CWRFA 141_ FYLMI 146_ TVAGI 151_ AFLYD 156_ KPWLY 161_ DLWEV 166_ WNGYP 171_ KQPLL 176_ PSQYW 181_ YYILE 186_ MSFYW 191_ SLLFR 196_ LGFDV 201_ KRKDF 206_ LAHII 211_ HHLAA 216_ ISLMS 221_ FSWCA 226_ NYIRS 231_ GTLVM 236_ IVHDV 241_ ADIWL 246_ ESAKM 251_ FSYAG 256_ WTQTC 261_ NTLFF 266_ IFSTI 271_ FFISR 276_ LIVFP 281_ FWILY 286_ CTLIL 291_ PMYHL 296_ EPFFS 301_ YIFLN 306_ LQLMI 311_ LQVLH 316_ LYWGY 321_ YILKM 326_ LNRCI 331_ FMKSI 336_ QDVRS 341_ DDEDY 346_ EEEEE 351_ EEEEE 356_ ATKGK 361_ EMDCL 366_ KNGLR 371_ AERHL 376_IPNGQ
1: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:17977534, PubMed:22038835, PubMed:26887952). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960)