Calcium homeostasis modulator protein 1 (Protein FAM26C)
1_MMDKF 6_ RMIFQ 11_ FLQSN 16_ QESFM 21_ NGICG 26_ IMALA 31_ SAQMY 36_ SAFDF 41_ NCPCL 46_ PGYNA 51_ AYSAG 56_ ILLAP 61_ PLVLF 66_ LLGLV 71_ MNNNV 76_ SMLAE 81_ EWKRP 86_ LGRRA 91_ KDPAV 96_ LRYMF 101_ CSMAQ 106_ RALIA 111_ PVVWV 116_ AVTLL 121_ DGKCF 126_ LCAFC 131_ TAVPV 136_ SALGN 141_ GSLAP 146_ GLPAP 151_ ELARL 156_ LARVP 161_ CPEIY 166_ DGDWL 171_ LAREV 176_ AVRYL 181_ RCISQ 186_ ALGWS 191_ FVLLT 196_ TLLAF 201_ VVRSV 206_ RPCFT 211_ QAAFL 216_ KSKYW 221_ SHYID 226_ IERKL 231_ FDETC 236_ TEHAK 241_ AFAKV 246_ CIQQF 251_ FEAMN 256_ HDLEL 261_ GHTHG 266_ TLATA 271_ PASAA 276_ APTTP 281_ DGAEE 286_ EREKL 291_ RGITD 296_ QGTMN 301_ RLLTS 306_ WHKCK 311_ PPLRL 316_ GQEEP 321_ PLMGN 326_ GWAGG 331_ GPRPP 336_ RKEVA 341_TYFSK
1: Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes (By similarity). With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity) (PubMed:23467090). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-) (PubMed:22711817, PubMed:23300080, PubMed:32832629, PubMed:37380652). Mediates Ca(2+) influx and downstream activation of the ERK1 and ERK2 cascade in neurons (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the Ca(2+) content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+)-dependent manner (PubMed:18585350)