TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
1_MACTG 6_ PSLPS 11_ AFDIL 16_ GAAGQ 21_ DKLLY 26_ LKHKL 31_ KTPRP 36_ GCQGQ 41_ DLLHA 46_ MVLLK 51_ LGQET 56_ EARIS 61_ LEALK 66_ ADAVA 71_ RLVAR 76_ QWAGV 81_ DSTED 86_ PEEPP 91_ DVSWA 96_ VARLY 101_ HLLAE 106_ EKLCP 111_ ASLRD 116_ VAYQE 121_ AVRTL 126_ SSRDD 131_ HRLGE 136_ LQDEA 141_ RNRCG 146_ WDIAG 151_ DPGSI 156_ RTLQS 161_ NLGCL 166_ PPSSA 171_ LPSGT 176_ RSLPR 181_ PIDGV 186_ SDWSQ 191_ GCSLR 196_ STGSP 201_ ASLAS 206_ NLEIS 211_ QSPTM 216_ PFLSL 221_ HRSPH 226_ GPSKL 231_ CDDPQ 236_ ASLVP 241_ EPVPG 246_ GCQEP 251_ EEMSW 256_ PPSGE 261_ IASPP 266_ ELPSS 271_ PPPGL 276_ PEVAP 281_ DATST 286_ GLPDT 291_ PAAPE 296_ TSTNY 301_ PVECT 306_ EGSAG 311_ PQSLP 316_ LPILE 321_ PVKNP 326_ CSVKD 331_ QTPLQ 336_ LSVED 341_ TTSPN 346_ TKPCP 351_ PTPTT 356_ PETSP 361_ PPPPP 366_ PPSST 371_ PCSAH 376_ LTPSS 381_ LFPSS 386_ LESSS 391_ EQKFY 396_ NFVIL 401_ HARAD 406_ EHIAL 411_ RVREK 416_ LEALG 421_ VPDGA 426_ TFCED 431_ FQVPG 436_ RGELS 441_ CLQDA 446_ IDHSA 451_ FIILL 456_ LTSNF 461_ DCRLS 466_ LHQVN 471_ QAMMS 476_ NLTRQ 481_ GSPDC 486_ VIPFL 491_ PLESS 496_ PAQLS 501_ SDTAS 506_ LLSGL 511_ VRLDE 516_ HSQIF 521_ ARKVA 526_ NTFKP 531_ HRLQA 536_ RKAMW 541_ RKEQD 546_ TRALR 551_ EQSQH 556_ LDGER 561_ MQAAA 566_ LNAAY 571_ SAYLQ 576_ SYLSY 581_ QAQME 586_ QLQVA 591_ FGSHM 596_ SFGTG 601_ APYGA 606_ RMPFG 611_ GQVPL 616_ GAPPP 621_ FPTWP 626_ GCPQP 631_ PPLHA 636_ WQAGT 641_ PPPPS 646_ PQPAA 651_ FPQSL 656_ PFPQS 661_ PAFPT 666_ ASPAP 671_ PQSPG 676_ LQPLI 681_ IHHAQ 686_ MVQLG 691_ LNNHM 696_ WNQRG 701_ SQAPE 706_DKTQE
1: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity)