Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13)
1_MRRFV 6_ YCKVV 11_ LATSL 16_ MWVLV 21_ DVFLL 26_ LYFSE 31_ CNKCD 36_ DKKER 41_ SLLPA 46_ LRAVI 51_ SRNQE 56_ GPGEM 61_ GKAVL 66_ IPKDD 71_ QEKMK 76_ ELFKI 81_ NQFNL 86_ MASDL 91_ IALNR 96_ SLPDV 101_ RLEGC 106_ KTKVY 111_ PDELP 116_ NTSVV 121_ IVFHN 126_ EAWST 131_ LLRTV 136_ YSVIN 141_ RSPHY 146_ LLSEV 151_ ILVDD 156_ ASERD 161_ FLKLT 166_ LENYV 171_ KNLEV 176_ PVKII 181_ RMEER 186_ SGLIR 191_ ARLRG 196_ AAASK 201_ GQVIT 206_ FLDAH 211_ CECTL 216_ GWLEP 221_ LLARI 226_ KEDRK 231_ TVVCP 236_ IIDVI 241_ SDDTF 246_ EYMAG 251_ SDMTY 256_ GGFNW 261_ KLNFR 266_ WYPVP 271_ QREMD 276_ RRKGD 281_ RTLPV 286_ RTPTM 291_ AGGLF 296_ SIDRN 301_ YFEEI 306_ GTYDA 311_ GMDIW 316_ GGENL 321_ EMSFR 326_ IWQCG 331_ GSLEI 336_ VTCSH 341_ VGHVF 346_ RKATP 351_ YTFPG 356_ GTGHV 361_ INKNN 366_ RRLAE 371_ VWMDE 376_ FKDFF 381_ YIISP 386_ GVVKV 391_ DYGDV 396_ SVRKT 401_ LRENL 406_ KCKPF 411_ SWYLE 416_ NIYPD 421_ SQIPR 426_ RYYSL 431_ GEIRN 436_ VETNQ 441_ CLDNM 446_ GRKEN 451_ EKVGI 456_ FNCHG 461_ MGGNQ 466_ VFSYT 471_ ADKEI 476_ RTDDL 481_ CLDVS 486_ RLNGP 491_ VIMLK 496_ CHHMR 501_ GNQLW 506_ EYDAE 511_ RLTLR 516_ HVNSN 521_ QCLDE 526_ PSEED 531_ KMVPT 536_ MQDCS 541_ GSRSQ 546_ QWLLR 551_NMTLG
1: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:22186971). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity) (PubMed:12407114, PubMed:22186971)
2: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain
3: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13)