E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
1_MAGLG 6_ LGSAV 11_ PVWLA 16_ EDDLG 21_ CIICQ 26_ GLLDW 31_ PATLP 36_ CGHSF 41_ CRHCL 46_ EALWG 51_ ARDAR 56_ RWACP 61_ TCRQG 66_ AAQQP 71_ HLRKN 76_ TLLQD 81_ LADKY 86_ RRAAR 91_ EIQAG 96_ SDPAH 101_ CPCPG 106_ SSSLS 111_ SAAAR 116_ PRRRP 121_ ELQRV 126_ AVEKS 131_ ITEVA 136_ QELTE 141_ LVEHL 146_ VDIVR 151_ SLQNQ 156_ RPLSE 161_ SGPDN 166_ ELSIL 171_ GKAFS 176_ SGVDL 181_ SMASP 186_ KLVTS 191_ DTAAG 196_ KIRDI 201_ LHDLE 206_ EIQEK 211_ LQESV 216_ TWKEA 221_ PEAQM 226_ QGELL 231_ EAPSS 236_ SSCPL 241_ PDQSH 246_ PALRR 251_ ASRFA 256_ QWAIH 261_ PTFNL 266_ KSLSC 271_ SLEVS 276_ KDSRT 281_ VTVSH 286_ RPQPY 291_ RWSCE 296_ RFSTS 301_ QVLCS 306_ QALSS 311_ GKHYW 316_ EVDTR 321_ NCSHW 326_ AVGVA 331_ SWEMS 336_ RDQVL 341_ GRTMD 346_ SCCVE 351_ WKGTS 356_ QLSAW 361_ HMVKE 366_ TVLGS 371_ DRPGV 376_ VGIWL 381_ NLEEG 386_ KLAFY 391_ SVDNQ 396_ EKLLY 401_ ECTIS 406_ ASSPL 411_ YPAFW 416_ LYGLH 421_ PGNYL 426_IIKQV
1: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531)