Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17)
1_MQREE 6_ GFNTK 11_ MADGP 16_ DEYDT 21_ EAGCV 26_ PLLHP 31_ EEIKP 36_ QSHYN 41_ HGYGE 46_ PLGRK 51_ THIDD 56_ YSTWD 61_ IVKAT 66_ QYGIY 71_ ERCRE 76_ LVEAG 81_ YDVRQ 86_ PDKEN 91_ VTLLH 96_ WAAIN 101_ NRIDL 106_ VKYYI 111_ SKGAI 116_ VDQLG 121_ GDLNS 126_ TPLHW 131_ ATRQG 136_ HLSMV 141_ VQLMK 146_ YGADP 151_ SLIDG 156_ EGCSC 161_ IHLAA 166_ QFGHT 171_ SIVAY 176_ LIAKG 181_ QDVDM 186_ MDQNG 191_ MTPLM 196_ WAAYR 201_ THSVD 206_ PTRLL 211_ LTFNV 216_ SVNLG 221_ DKYHK 226_ NTALH 231_ WAVLA 236_ GNTTV 241_ ISLLL 246_ EAGAN 251_ VDAQN 256_ IKGES 261_ ALDLA 266_ KQRKN 271_ VWMIN 276_ HLQEA 281_ RQAKG 286_ YDNPS 291_ FLRKL 296_ KADKE 301_ FRQKV 306_ MLGTP 311_ FLVIW 316_ LVGFI 321_ ADLNI 326_ DSWLI 331_ KGLMY 336_ GGVWA 341_ TVQFL 346_ SKSFF 351_ DHSMH 356_ SALPL 361_ GIYLA 366_ TKFWM 371_ YVTWF 376_ FWFWN 381_ DLNFL 386_ FIHLP 391_ FLANS 396_ VALFY 401_ NFGKS 406_ WKSDP 411_ GIIKA 416_ TEEQK 421_ KKTIV 426_ ELAET 431_ GSLDL 436_ SIFCS 441_ TCLIR 446_ KPVRS 451_ KHCGV 456_ CNRCI 461_ AKFDH 466_ HCPWV 471_ GNCVG 476_ AGNHR 481_ YFMGY 486_ LFFLL 491_ FMICW 496_ MIYGC 501_ ISYWG 506_ LHCET 511_ TYTKD 516_ GFWTY 521_ ITQIA 526_ TCSPW 531_ MFWMF 536_ LNSVF 541_ HFMWV 546_ AVLLM 551_ CQMYQ 556_ ISCLG 561_ ITTNE 566_ RMNAR 571_ RYKHF 576_ KVTTT 581_ SIESP 586_ FNHGC 591_ VRNII 596_ DFFEF 601_ RCCGL 606_ FRPVI 611_ VDWTR 616_ QYTIE 621_ YDQIS 626_GSGYQ
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603740, PubMed:24705354, PubMed:27911442, PubMed:28757145). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603740, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442)