Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5)
1_MACLG 6_ FLLPV 11_ GFLLL 16_ ISTVA 21_ GGKYG 26_ VAHVV 31_ SENWS 36_ KDYCI 41_ LFSSD 46_ YITLP 51_ RDLHH 56_ APLLP 61_ LYDGT 66_ KAPWC 71_ PGEDS 76_ PHQAQ 81_ LRSPS 86_ QRPLR 91_ QTTAM 96_ VMRGN 101_ CSFHT 106_ KGWLA 111_ QGQGA 116_ HGLLI 121_ VSRVS 126_ DQQCS 131_ DTTLA 136_ PQDPR 141_ QPLAD 146_ LTIPV 151_ AMLHY 156_ ADMLD 161_ ILSHT 166_ RGEAV 171_ VRVAM 176_ YAPPE 181_ PIIDY 186_ NMLVI 191_ FILAV 196_ GTVAA 201_ GGYWA 206_ GLTEA 211_ NRLQR 216_ RRARR 221_ GGGSG 226_ GHHQL 231_ QEAAA 236_ AEGAQ 241_ KEDNE 246_ DIPVD 251_ FTPAM 256_ TGVVV 261_ TLSCS 266_ LMLLL 271_ YFFYD 276_ HFVYV 281_ TIGIF 286_ GLGAG 291_ IGLYS 296_ CLSPL 301_ VCRLS 306_ LRQYQ 311_ RPPHS 316_ LWASL 321_ PLPLL 326_ LLASL 331_ CATVI 336_ IFWVA 341_ YRNED 346_ RWAWL 351_ LQDTL 356_ GISYC 361_ LFVLH 366_ RVRLP 371_ TLKNC 376_ SSFLL 381_ ALLAF 386_ DVFFV 391_ FVTPF 396_ FTKTG 401_ ESIMA 406_ QVALG 411_ PAESS 416_ SHERL 421_ PMVLK 426_ VPRLR 431_ VSALT 436_ LCSQP 441_ FSILG 446_ FGDIV 451_ VPGFL 456_ VAYCC 461_ RFDVQ 466_ VCSRQ 471_ IYFVA 476_ CTVAY 481_ AVGLL 486_ VTFMA 491_ MVLMQ 496_ MGQPA 501_ LLYLV 506_ SSTLL 511_ TSLAV 516_ AACRQ 521_ ELSLF 526_ WTGQG 531_ RAKMC 536_ GLGCA 541_ PSAGS 546_ RQKQE 551_ GAADA 556_ HTAST 561_ LERGT 566_ SRGAG 571_ DLDSN 576_ PGEDT 581_ TEIVT 586_ ISENE 591_ ATNPE 596_ DRSDS 601_ SEGWS 606_ DAHLD 611_ PNELP 616_ FIPPG 621_ ASEEL 626_ MPLMP 631_ MAMLI 636_ PLMPL 641_ MPPPS 646_ ELGHV 651_ HAQAQ 656_ AHETG 661_ LPWAG 666_ LHKRK 671_ GLKVR 676_KSMST
1: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281)
2: In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners